TY - JOUR
T1 - Physical activity and incident cognitive impairment in elderly persons
T2 - The INVADE study
AU - Etgen, Thorleif
AU - Sander, Dirk
AU - Huntgeburth, Ulrich
AU - Poppert, Holger
AU - Förstl, Hans
AU - Bickel, Horst
PY - 2010/1/25
Y1 - 2010/1/25
N2 - Background: Data regarding the relationship between physical activity and cognitive impairment are limited and controversial. We examined whether physical activity is associated with incident cognitive impairment during follow-up. Methods: As part of a community-based prospective cohort study in southern Bavaria, Germany, 3903 participants older than 55 years were enrolled between 2001 and 2003 and followed up for 2 years. Physical activity (classified as no activity, moderate activity [<3 times/wk], and high activity [≥3 times/wk]), cognitive function (assessed by the 6-Item Cognitive Impairment Test), and potential confounders were evaluated. The main outcome measure was incident cognitive impairment after 2 years of follow-up. Results: At baseline, 418 participants (10.7%) had cognitive impairment. After a 2-year follow-up, 207 of 3485 initially unimpaired subjects (5.9%) developed incident cognitive impairment. Compared with participants without physical activity, fully adjusted multiple logistic regression analysis showed a significantly reduced risk of incident cognitive impairment after 2 years for participants with moderate or high physical activity at baseline (odds ratio [OR], 0.57; 95% confidence interval [CI], 0.37-0.87 [P=.01]; and OR, 0.54; 95% CI, 0.35-0.83 [P=.005]; respectively). Further subanalysis including participants (n=2029) without functional impairment and without prodromal phase of dementia resulted in an even higher reduction of risk of incident cognitive impairment for participants with moderate or high physical activity (OR, 0.44; 95% CI, 0.24-0.83 [P=.01]; and OR, 0.46; 95% CI, 0.25-0.85 [P=.01]; respectively) compared with no activity. Conclusion: Moderate or high physical activity is associated with a reduced incidence of cognitive impairment after 2 years in a large population-based cohort of elderly subjects.
AB - Background: Data regarding the relationship between physical activity and cognitive impairment are limited and controversial. We examined whether physical activity is associated with incident cognitive impairment during follow-up. Methods: As part of a community-based prospective cohort study in southern Bavaria, Germany, 3903 participants older than 55 years were enrolled between 2001 and 2003 and followed up for 2 years. Physical activity (classified as no activity, moderate activity [<3 times/wk], and high activity [≥3 times/wk]), cognitive function (assessed by the 6-Item Cognitive Impairment Test), and potential confounders were evaluated. The main outcome measure was incident cognitive impairment after 2 years of follow-up. Results: At baseline, 418 participants (10.7%) had cognitive impairment. After a 2-year follow-up, 207 of 3485 initially unimpaired subjects (5.9%) developed incident cognitive impairment. Compared with participants without physical activity, fully adjusted multiple logistic regression analysis showed a significantly reduced risk of incident cognitive impairment after 2 years for participants with moderate or high physical activity at baseline (odds ratio [OR], 0.57; 95% confidence interval [CI], 0.37-0.87 [P=.01]; and OR, 0.54; 95% CI, 0.35-0.83 [P=.005]; respectively). Further subanalysis including participants (n=2029) without functional impairment and without prodromal phase of dementia resulted in an even higher reduction of risk of incident cognitive impairment for participants with moderate or high physical activity (OR, 0.44; 95% CI, 0.24-0.83 [P=.01]; and OR, 0.46; 95% CI, 0.25-0.85 [P=.01]; respectively) compared with no activity. Conclusion: Moderate or high physical activity is associated with a reduced incidence of cognitive impairment after 2 years in a large population-based cohort of elderly subjects.
UR - http://www.scopus.com/inward/record.url?scp=75749138532&partnerID=8YFLogxK
U2 - 10.1001/archinternmed.2009.498
DO - 10.1001/archinternmed.2009.498
M3 - Article
C2 - 20101014
AN - SCOPUS:75749138532
SN - 0003-9926
VL - 170
SP - 186
EP - 193
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 2
ER -