Photoswitched cell adhesion on surfaces with RGD peptides

Jörg Auernheimer; Claudia Dahmen; Ulrich Hersel; Andreas Bausch; Horst Kessler

doi:10.1021/ja053648q

Photoswitched cell adhesion on surfaces with RGD peptides

Jörg Auernheimer, Claudia Dahmen, Ulrich Hersel, Andreas Bausch, Horst Kessler

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

199 Scopus citations

Abstract

Coating of surfaces by RGD peptides is well-known. Herein we describe the possibility to switch cell adhesion properties by changing the distance and orientation of the RGD peptides to the surface. A set of RGD peptides of the type cyclo(-RGDfK-) was synthesized containing the photoswitchable 4-[(4-aminophenyl)azo]benzocarbonyl central unit as spacer between the acrylamide anchor and the RGD peptide. PMMA (poly methyl methacrylate) surfaces were coated with these peptides. Control of adhesion stimulation by irradiation with 366 or 450 nm light could be achieved.

Original language	English
Pages (from-to)	16107-16110
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	127
Issue number	46
DOIs	https://doi.org/10.1021/ja053648q
State	Published - 23 Nov 2005

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AU - Auernheimer, Jörg

AU - Dahmen, Claudia

AU - Hersel, Ulrich

AU - Bausch, Andreas

AU - Kessler, Horst

PY - 2005/11/23

Y1 - 2005/11/23

N2 - Coating of surfaces by RGD peptides is well-known. Herein we describe the possibility to switch cell adhesion properties by changing the distance and orientation of the RGD peptides to the surface. A set of RGD peptides of the type cyclo(-RGDfK-) was synthesized containing the photoswitchable 4-[(4-aminophenyl)azo]benzocarbonyl central unit as spacer between the acrylamide anchor and the RGD peptide. PMMA (poly methyl methacrylate) surfaces were coated with these peptides. Control of adhesion stimulation by irradiation with 366 or 450 nm light could be achieved.

AB - Coating of surfaces by RGD peptides is well-known. Herein we describe the possibility to switch cell adhesion properties by changing the distance and orientation of the RGD peptides to the surface. A set of RGD peptides of the type cyclo(-RGDfK-) was synthesized containing the photoswitchable 4-[(4-aminophenyl)azo]benzocarbonyl central unit as spacer between the acrylamide anchor and the RGD peptide. PMMA (poly methyl methacrylate) surfaces were coated with these peptides. Control of adhesion stimulation by irradiation with 366 or 450 nm light could be achieved.

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 46

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Photoswitched cell adhesion on surfaces with RGD peptides

Abstract

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