Photosensitizing properties of compounds related to benzophenone

Marianne Placzek, Markus Dendorfer, Bernhard Przybilla, Klaus P. Gilbertz, Bernadette Eberlein

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Benzophenone is a phototoxic compound with absorption maxima in the ultraviolet A (UVA) and ultraviolet B (UVB) range. Many benzophenone derivatives are known to be photosensitizing. On the other hand, 2-hy-droxy-4-methoxybenzophenone is used as a photoprotec-tive agent. The aim of the present study was to analyse a range of benzophenone derivatives and thus examine the effects of molecular changes in the benzophenone molecule on phototoxic behaviour. Phototoxicity was tested by an in vitro photohaemolysis test. The tested compounds were benzophenone itself and the derivatives 2-hydroxy-benzophenone, 2-aminobenzophenone, 2-benzoylbenzoic acid, 3-hydroxybenzophenone, and 4-hydroxybenzo-phenone, as well as the structurally similar compounds 9-fuorenone, 9-fuorenone-2-carboxylic acid, cyclohexyl phenyl ketone, and 1,4-naphtho-quinone. It was shown that minor changes in molecular structure can result in highly different phototoxic characteristics.

Original languageEnglish
Pages (from-to)30-32
Number of pages3
JournalActa Dermato-Venereologica
Volume93
Issue number1
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Benzophenone
  • Photohaemolysis test
  • Phototoxicity

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