Photon attenuation correction in misregistered cardiac PET/CT

A. Martinez-Möller; N. Navab; M. Schwaiger; S. G. Nekolla

doi:10.1007/978-3-540-71091-2_46

Photon attenuation correction in misregistered cardiac PET/CT

A. Martinez-Möller
, N. Navab
, M. Schwaiger
, S. G. Nekolla

Technical University of Munich

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

PET-CT misalignment has been reported as a source of artefacts in cardiac PET/CT due to a biased photon attenuation correction. Using the data from 28 cardiac PET/CT rest/stress examinations, PET-CT misalignment was corrected using three different methods: manual registration, automatic mutual information based image registration and an emission-driven correction algorithm. The clinical effects of the realignment were quantitatively assessed, and significant changes were observed in 6 out of 28 examinations (21.4%), in 5 of these studies resulting in the disappearance of large apparent perfusion defects. These results indicate that the excellent specificity of PET for the detection of perfusion defects could be compromised when CT-based attenuation correction is done without correction of PET-CT misalignment.

Original language	English
Title of host publication	Bildverarbeitung fur die Medizin 2007
Subtitle of host publication	Algorithmen - Systeme - Anwendungen, BVM 2007 - Proceedings des Workshops
Publisher	Kluwer Academic Publishers
Pages	227-231
Number of pages	5
ISBN (Print)	3540710906, 9783540710905
DOIs	https://doi.org/10.1007/978-3-540-71091-2_46
State	Published - 2007
Event	Workshops Bildverarbeitung fur die Medizin: Algorithmen - Systeme - Anwendungen, BVM 2007 - Workshop on Image Processing for Medicine: Algorithms - Systems - Applications, BVM 2007 - Munich, Germany Duration: 25 Mar 2007 → 27 Mar 2007

Publication series

Name	Informatik aktuell
ISSN (Print)	1431-472X

Conference

Conference	Workshops Bildverarbeitung fur die Medizin: Algorithmen - Systeme - Anwendungen, BVM 2007 - Workshop on Image Processing for Medicine: Algorithms - Systems - Applications, BVM 2007
Country/Territory	Germany
City	Munich
Period	25/03/07 → 27/03/07

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@inproceedings{d790af3e48e640f7aa847b7ee44c313a,

title = "Photon attenuation correction in misregistered cardiac PET/CT",

abstract = "PET-CT misalignment has been reported as a source of artefacts in cardiac PET/CT due to a biased photon attenuation correction. Using the data from 28 cardiac PET/CT rest/stress examinations, PET-CT misalignment was corrected using three different methods: manual registration, automatic mutual information based image registration and an emission-driven correction algorithm. The clinical effects of the realignment were quantitatively assessed, and significant changes were observed in 6 out of 28 examinations (21.4\%), in 5 of these studies resulting in the disappearance of large apparent perfusion defects. These results indicate that the excellent specificity of PET for the detection of perfusion defects could be compromised when CT-based attenuation correction is done without correction of PET-CT misalignment.",

author = "A. Martinez-M{\"o}ller and N. Navab and M. Schwaiger and Nekolla, \{S. G.\}",

year = "2007",

doi = "10.1007/978-3-540-71091-2\_46",

language = "English",

isbn = "3540710906",

series = "Informatik aktuell",

publisher = "Kluwer Academic Publishers",

pages = "227--231",

booktitle = "Bildverarbeitung fur die Medizin 2007",

note = "Workshops Bildverarbeitung fur die Medizin: Algorithmen - Systeme - Anwendungen, BVM 2007 - Workshop on Image Processing for Medicine: Algorithms - Systems - Applications, BVM 2007 ; Conference date: 25-03-2007 Through 27-03-2007",

}

Martinez-Möller, A, Navab, N , Schwaiger, M & Nekolla, SG 2007, Photon attenuation correction in misregistered cardiac PET/CT. in Bildverarbeitung fur die Medizin 2007: Algorithmen - Systeme - Anwendungen, BVM 2007 - Proceedings des Workshops. Informatik aktuell, Kluwer Academic Publishers, pp. 227-231, Workshops Bildverarbeitung fur die Medizin: Algorithmen - Systeme - Anwendungen, BVM 2007 - Workshop on Image Processing for Medicine: Algorithms - Systems - Applications, BVM 2007, Munich, Germany, 25/03/07. https://doi.org/10.1007/978-3-540-71091-2_46

Photon attenuation correction in misregistered cardiac PET/CT. / Martinez-Möller, A.; Navab, N.; Schwaiger, M. et al.
Bildverarbeitung fur die Medizin 2007: Algorithmen - Systeme - Anwendungen, BVM 2007 - Proceedings des Workshops. Kluwer Academic Publishers, 2007. p. 227-231 (Informatik aktuell).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Photon attenuation correction in misregistered cardiac PET/CT

AU - Martinez-Möller, A.

AU - Navab, N.

AU - Schwaiger, M.

AU - Nekolla, S. G.

PY - 2007

Y1 - 2007

N2 - PET-CT misalignment has been reported as a source of artefacts in cardiac PET/CT due to a biased photon attenuation correction. Using the data from 28 cardiac PET/CT rest/stress examinations, PET-CT misalignment was corrected using three different methods: manual registration, automatic mutual information based image registration and an emission-driven correction algorithm. The clinical effects of the realignment were quantitatively assessed, and significant changes were observed in 6 out of 28 examinations (21.4%), in 5 of these studies resulting in the disappearance of large apparent perfusion defects. These results indicate that the excellent specificity of PET for the detection of perfusion defects could be compromised when CT-based attenuation correction is done without correction of PET-CT misalignment.

AB - PET-CT misalignment has been reported as a source of artefacts in cardiac PET/CT due to a biased photon attenuation correction. Using the data from 28 cardiac PET/CT rest/stress examinations, PET-CT misalignment was corrected using three different methods: manual registration, automatic mutual information based image registration and an emission-driven correction algorithm. The clinical effects of the realignment were quantitatively assessed, and significant changes were observed in 6 out of 28 examinations (21.4%), in 5 of these studies resulting in the disappearance of large apparent perfusion defects. These results indicate that the excellent specificity of PET for the detection of perfusion defects could be compromised when CT-based attenuation correction is done without correction of PET-CT misalignment.

UR - https://www.scopus.com/pages/publications/84879928798

U2 - 10.1007/978-3-540-71091-2_46

DO - 10.1007/978-3-540-71091-2_46

M3 - Conference contribution

AN - SCOPUS:84879928798

SN - 3540710906

SN - 9783540710905

T3 - Informatik aktuell

SP - 227

EP - 231

BT - Bildverarbeitung fur die Medizin 2007

PB - Kluwer Academic Publishers

T2 - Workshops Bildverarbeitung fur die Medizin: Algorithmen - Systeme - Anwendungen, BVM 2007 - Workshop on Image Processing for Medicine: Algorithms - Systems - Applications, BVM 2007

Y2 - 25 March 2007 through 27 March 2007

ER -

Photon attenuation correction in misregistered cardiac PET/CT

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