Photoactivated Release of Cargo from the Cavity of Polyelectrolyte Capsules to the Cytosol of Cells

A. Muñoz Javier; P. Del Pino; M. F. Bedard; D. Ho; A. G. Skirtach; G. B. Sukhorukov; C. Plank; W. J. Parak

doi:10.1201/9781003306498-46

Photoactivated Release of Cargo from the Cavity of Polyelectrolyte Capsules to the Cytosol of Cells

A. Muñoz Javier, P. Del Pino, M. F. Bedard, D. Ho, A. G. Skirtach, G. B. Sukhorukov, C. Plank, W. J. Parak

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Polyelectrolyte capsules with metal nanoparticles in their walls and fluorescently labeled polymers as cargo inside their cavity were prepared. Capsules were ingested by living cells with no uncontrolled release of the cargo upon the incorporation process. Photoinduced heating of the metal nanoparticles in the capsule walls lead to rupture of the capsule walls, and the polymeric cargo was released to the whole cytosol. Viability tests demonstrate that opening of capsules at moderate light intensities does not impair the cellular metabolism, whereas capsule opening at high light intensities ultimately leads to cell death.

Original language	English
Title of host publication	Bio-Nano Interfaces
Subtitle of host publication	Perspectives, Properties, and Applications
Publisher	Jenny Stanford Publishing
Pages	1155-1168
Number of pages	14
ISBN (Electronic)	9781000618907
ISBN (Print)	9789814877831
DOIs	https://doi.org/10.1201/9781003306498-46
State	Published - 1 Jan 2024
Externally published	Yes

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Muñoz Javier, A., Del Pino, P., Bedard, M. F., Ho, D., Skirtach, A. G., Sukhorukov, G. B., Plank, C., & Parak, W. J. (2024). Photoactivated Release of Cargo from the Cavity of Polyelectrolyte Capsules to the Cytosol of Cells. In Bio-Nano Interfaces: Perspectives, Properties, and Applications (pp. 1155-1168). Jenny Stanford Publishing. https://doi.org/10.1201/9781003306498-46

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abstract = "Polyelectrolyte capsules with metal nanoparticles in their walls and fluorescently labeled polymers as cargo inside their cavity were prepared. Capsules were ingested by living cells with no uncontrolled release of the cargo upon the incorporation process. Photoinduced heating of the metal nanoparticles in the capsule walls lead to rupture of the capsule walls, and the polymeric cargo was released to the whole cytosol. Viability tests demonstrate that opening of capsules at moderate light intensities does not impair the cellular metabolism, whereas capsule opening at high light intensities ultimately leads to cell death.",

author = "{Mu{\~n}oz Javier}, A. and {Del Pino}, P. and Bedard, {M. F.} and D. Ho and Skirtach, {A. G.} and Sukhorukov, {G. B.} and C. Plank and Parak, {W. J.}",

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doi = "10.1201/9781003306498-46",

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T1 - Photoactivated Release of Cargo from the Cavity of Polyelectrolyte Capsules to the Cytosol of Cells

AU - Muñoz Javier, A.

AU - Del Pino, P.

AU - Bedard, M. F.

AU - Ho, D.

AU - Skirtach, A. G.

AU - Sukhorukov, G. B.

AU - Plank, C.

AU - Parak, W. J.

PY - 2024/1/1

Y1 - 2024/1/1

N2 - Polyelectrolyte capsules with metal nanoparticles in their walls and fluorescently labeled polymers as cargo inside their cavity were prepared. Capsules were ingested by living cells with no uncontrolled release of the cargo upon the incorporation process. Photoinduced heating of the metal nanoparticles in the capsule walls lead to rupture of the capsule walls, and the polymeric cargo was released to the whole cytosol. Viability tests demonstrate that opening of capsules at moderate light intensities does not impair the cellular metabolism, whereas capsule opening at high light intensities ultimately leads to cell death.

AB - Polyelectrolyte capsules with metal nanoparticles in their walls and fluorescently labeled polymers as cargo inside their cavity were prepared. Capsules were ingested by living cells with no uncontrolled release of the cargo upon the incorporation process. Photoinduced heating of the metal nanoparticles in the capsule walls lead to rupture of the capsule walls, and the polymeric cargo was released to the whole cytosol. Viability tests demonstrate that opening of capsules at moderate light intensities does not impair the cellular metabolism, whereas capsule opening at high light intensities ultimately leads to cell death.

UR - http://www.scopus.com/inward/record.url?scp=85216264608&partnerID=8YFLogxK

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DO - 10.1201/9781003306498-46

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EP - 1168

BT - Bio-Nano Interfaces

PB - Jenny Stanford Publishing

ER -

Photoactivated Release of Cargo from the Cavity of Polyelectrolyte Capsules to the Cytosol of Cells

Abstract

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