Pharmacotherapeutic Management of Pancreatic Ductal Adenocarcinoma: Current and Emerging Concepts

Dietrich A. Ruess, Kivanc Görgülü, Sonja M. Wörmann, Hana Algül

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma is a devastating malignancy, which is the result of late diagnosis, aggressive disease, and a lack of effective treatment options. Thus, pancreatic ductal adenocarcinoma is projected to become the second leading cause of cancer-related death by 2030. This review summarizes recent developments of oncological therapy in the palliative setting of metastatic pancreatic ductal adenocarcinoma. It further compiles novel targets and therapeutic approaches as well as promising treatment combinations, which are presently in preclinical evaluation, covering several aspects of the hallmarks of cancer. Finally, challenges to the implementation of an individualized therapy approach in the context of precision medicine are discussed.

Original languageEnglish
Pages (from-to)331-357
Number of pages27
JournalDrugs and Aging
Volume34
Issue number5
DOIs
StatePublished - 1 May 2017

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