Pharmacological Targeting of the Actin Cytoskeleton to Drive Endocrinogenesis

Johanna Siehler, Anna Karolina Blöchinger, Heiko Lickert

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations

Abstract

In vitro generation of insulin-secreting beta cells from human pluripotent stem cells (hPSCs) opens new avenues for treating and modeling diabetes. Hogrebe and colleaguesestablished a new 2D differentiation protocol where they targeted the cytoskeleton pharmacologically for controlled endocrine induction and generation of hPSC-derived beta cells with improved function.

Original languageEnglish
Pages (from-to)384-386
Number of pages3
JournalTrends in Pharmacological Sciences
Volume41
Issue number6
DOIs
StatePublished - Jun 2020
Externally publishedYes

Keywords

  • Latrunculin A
  • actin
  • beta cells
  • endocrine progenitors
  • pancreatic progenitors
  • stem cells

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