Pharmacological Targeting of the Actin Cytoskeleton to Drive Endocrinogenesis

Johanna Siehler; Anna Karolina Blöchinger; Heiko Lickert

doi:10.1016/j.tips.2020.04.002

Pharmacological Targeting of the Actin Cytoskeleton to Drive Endocrinogenesis

Johanna Siehler, Anna Karolina Blöchinger, Heiko Lickert

Department of Pediatric Medicine

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

In vitro generation of insulin-secreting beta cells from human pluripotent stem cells (hPSCs) opens new avenues for treating and modeling diabetes. Hogrebe and colleaguesestablished a new 2D differentiation protocol where they targeted the cytoskeleton pharmacologically for controlled endocrine induction and generation of hPSC-derived beta cells with improved function.

Original language	English
Pages (from-to)	384-386
Number of pages	3
Journal	Trends in Pharmacological Sciences
Volume	41
Issue number	6
DOIs	https://doi.org/10.1016/j.tips.2020.04.002
State	Published - Jun 2020

Keywords

Latrunculin A
actin
beta cells
endocrine progenitors
pancreatic progenitors
stem cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tips.2020.04.002

Cite this

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title = "Pharmacological Targeting of the Actin Cytoskeleton to Drive Endocrinogenesis",

abstract = "In vitro generation of insulin-secreting beta cells from human pluripotent stem cells (hPSCs) opens new avenues for treating and modeling diabetes. Hogrebe and colleaguesestablished a new 2D differentiation protocol where they targeted the cytoskeleton pharmacologically for controlled endocrine induction and generation of hPSC-derived beta cells with improved function.",

keywords = "Latrunculin A, actin, beta cells, endocrine progenitors, pancreatic progenitors, stem cells",

author = "Johanna Siehler and Bl{\"o}chinger, {Anna Karolina} and Heiko Lickert",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = jun,

doi = "10.1016/j.tips.2020.04.002",

language = "English",

volume = "41",

pages = "384--386",

journal = "Trends in Pharmacological Sciences",

issn = "0165-6147",

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number = "6",

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TY - JOUR

T1 - Pharmacological Targeting of the Actin Cytoskeleton to Drive Endocrinogenesis

AU - Siehler, Johanna

AU - Blöchinger, Anna Karolina

AU - Lickert, Heiko

PY - 2020/6

Y1 - 2020/6

N2 - In vitro generation of insulin-secreting beta cells from human pluripotent stem cells (hPSCs) opens new avenues for treating and modeling diabetes. Hogrebe and colleaguesestablished a new 2D differentiation protocol where they targeted the cytoskeleton pharmacologically for controlled endocrine induction and generation of hPSC-derived beta cells with improved function.

AB - In vitro generation of insulin-secreting beta cells from human pluripotent stem cells (hPSCs) opens new avenues for treating and modeling diabetes. Hogrebe and colleaguesestablished a new 2D differentiation protocol where they targeted the cytoskeleton pharmacologically for controlled endocrine induction and generation of hPSC-derived beta cells with improved function.

KW - Latrunculin A

KW - actin

KW - beta cells

KW - endocrine progenitors

KW - pancreatic progenitors

KW - stem cells

UR - http://www.scopus.com/inward/record.url?scp=85083676266&partnerID=8YFLogxK

U2 - 10.1016/j.tips.2020.04.002

DO - 10.1016/j.tips.2020.04.002

M3 - Short survey

C2 - 32340752

AN - SCOPUS:85083676266

SN - 0165-6147

VL - 41

SP - 384

EP - 386

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 6

ER -

Pharmacological Targeting of the Actin Cytoskeleton to Drive Endocrinogenesis

Abstract

Keywords

UN SDGs

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