Pharmacokinetics of vinyl chloride in the rhesus monkey

A. Buchter; J. G. Filser; H. Peter; H. M. Bolt

doi:10.1016/0378-4274(80)90099-5

Pharmacokinetics of vinyl chloride in the rhesus monkey

A. Buchter, J. G. Filser, H. Peter, H. M. Bolt

University of Cologne

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The metabolic elimination of vinyl chloride in Rhesus monkeys is a dosedependent, saturable process, as in rats. Below 200-300 ppm of vinyl chloride (VC) in atmosphere, elimination obeys a first-order law; the clearance rate is much closer to that found in man than the values for rats, mice and gerbils. The maximal velocity of metabolic elimination of VC at high concentrations in Rhesus monkeys is only about half that of rats when related to kg body weight. It is suggested that Rhesus monkeys mimic the quantitative aspects of VC metabolism better than rats or mice.

Original language	English
Pages (from-to)	33-36
Number of pages	4
Journal	Toxicology Letters
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/0378-4274(80)90099-5
State	Published - Jun 1980
Externally published	Yes

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abstract = "The metabolic elimination of vinyl chloride in Rhesus monkeys is a dosedependent, saturable process, as in rats. Below 200-300 ppm of vinyl chloride (VC) in atmosphere, elimination obeys a first-order law; the clearance rate is much closer to that found in man than the values for rats, mice and gerbils. The maximal velocity of metabolic elimination of VC at high concentrations in Rhesus monkeys is only about half that of rats when related to kg body weight. It is suggested that Rhesus monkeys mimic the quantitative aspects of VC metabolism better than rats or mice.",

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AU - Peter, H.

AU - Bolt, H. M.

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AB - The metabolic elimination of vinyl chloride in Rhesus monkeys is a dosedependent, saturable process, as in rats. Below 200-300 ppm of vinyl chloride (VC) in atmosphere, elimination obeys a first-order law; the clearance rate is much closer to that found in man than the values for rats, mice and gerbils. The maximal velocity of metabolic elimination of VC at high concentrations in Rhesus monkeys is only about half that of rats when related to kg body weight. It is suggested that Rhesus monkeys mimic the quantitative aspects of VC metabolism better than rats or mice.

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Pharmacokinetics of vinyl chloride in the rhesus monkey

Abstract

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