PGFM response to exogenous oxytocin and determination of the half-life of oxytocin in nonpregnant mares

D. L. Paccamonti; J. F. Pycock; M. A.M. Taverne; M. Bevers; G. C. Van Der Weijden; S. Gutjahr; D. Schams; D. Blouin

doi:10.1111/j.2042-3306.1999.tb03818.x

PGFM response to exogenous oxytocin and determination of the half-life of oxytocin in nonpregnant mares

D. L. Paccamonti
, J. F. Pycock
, M. A.M. Taverne
, M. Bevers
, G. C. Van Der Weijden
, S. Gutjahr
, D. Schams
, D. Blouin

Chair of Animal Physiology and Immunology

the University of Utrecht
School of Veterinary Medicine
Howe Farm Cottage
University of Leipzig
Louisiana State University

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

We investigated the half-life of oxytocin in reproductively normal mares and the prostaglandin response after oxytocin administrations. Mares were given oxytocin, 10 or 25 iu, i.v., on the day of, or 2 days after, ovulation, and frequent jugular blood samples were collected for analysis of oxytocin and Prostaglandin F metabolite (PGFM) by RIA. Neither dose of oxytocin nor day of treatment affected the half-life of the exogenous oxytocin, which was determined to be 6.8 min. A significant increase in PGFM was observed within 6 min of oxytocin administration and peak values were observed within 10 min. PGFM response after oxytocin administration on the day of ovulation appeared elevated compared to the response 2 days after ovulation.

Original language	English
Pages (from-to)	285-288
Number of pages	4
Journal	Equine Veterinary Journal
Volume	31
Issue number	4
DOIs	https://doi.org/10.1111/j.2042-3306.1999.tb03818.x
State	Published - Jul 1999

Keywords

Horse
Mare
Oxytocin
Prostaglandin
Uterus

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10.1111/j.2042-3306.1999.tb03818.x

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title = "PGFM response to exogenous oxytocin and determination of the half-life of oxytocin in nonpregnant mares",

abstract = "We investigated the half-life of oxytocin in reproductively normal mares and the prostaglandin response after oxytocin administrations. Mares were given oxytocin, 10 or 25 iu, i.v., on the day of, or 2 days after, ovulation, and frequent jugular blood samples were collected for analysis of oxytocin and Prostaglandin F metabolite (PGFM) by RIA. Neither dose of oxytocin nor day of treatment affected the half-life of the exogenous oxytocin, which was determined to be 6.8 min. A significant increase in PGFM was observed within 6 min of oxytocin administration and peak values were observed within 10 min. PGFM response after oxytocin administration on the day of ovulation appeared elevated compared to the response 2 days after ovulation.",

keywords = "Horse, Mare, Oxytocin, Prostaglandin, Uterus",

author = "Paccamonti, \{D. L.\} and Pycock, \{J. F.\} and Taverne, \{M. A.M.\} and M. Bevers and \{Van Der Weijden\}, \{G. C.\} and S. Gutjahr and D. Schams and D. Blouin",

year = "1999",

month = jul,

doi = "10.1111/j.2042-3306.1999.tb03818.x",

language = "English",

volume = "31",

pages = "285--288",

journal = "Equine Veterinary Journal",

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TY - JOUR

T1 - PGFM response to exogenous oxytocin and determination of the half-life of oxytocin in nonpregnant mares

AU - Paccamonti, D. L.

AU - Pycock, J. F.

AU - Taverne, M. A.M.

AU - Bevers, M.

AU - Van Der Weijden, G. C.

AU - Gutjahr, S.

AU - Schams, D.

AU - Blouin, D.

PY - 1999/7

Y1 - 1999/7

N2 - We investigated the half-life of oxytocin in reproductively normal mares and the prostaglandin response after oxytocin administrations. Mares were given oxytocin, 10 or 25 iu, i.v., on the day of, or 2 days after, ovulation, and frequent jugular blood samples were collected for analysis of oxytocin and Prostaglandin F metabolite (PGFM) by RIA. Neither dose of oxytocin nor day of treatment affected the half-life of the exogenous oxytocin, which was determined to be 6.8 min. A significant increase in PGFM was observed within 6 min of oxytocin administration and peak values were observed within 10 min. PGFM response after oxytocin administration on the day of ovulation appeared elevated compared to the response 2 days after ovulation.

AB - We investigated the half-life of oxytocin in reproductively normal mares and the prostaglandin response after oxytocin administrations. Mares were given oxytocin, 10 or 25 iu, i.v., on the day of, or 2 days after, ovulation, and frequent jugular blood samples were collected for analysis of oxytocin and Prostaglandin F metabolite (PGFM) by RIA. Neither dose of oxytocin nor day of treatment affected the half-life of the exogenous oxytocin, which was determined to be 6.8 min. A significant increase in PGFM was observed within 6 min of oxytocin administration and peak values were observed within 10 min. PGFM response after oxytocin administration on the day of ovulation appeared elevated compared to the response 2 days after ovulation.

KW - Horse

KW - Mare

KW - Oxytocin

KW - Prostaglandin

KW - Uterus

UR - https://www.scopus.com/pages/publications/0033162821

U2 - 10.1111/j.2042-3306.1999.tb03818.x

DO - 10.1111/j.2042-3306.1999.tb03818.x

M3 - Article

C2 - 10454085

AN - SCOPUS:0033162821

SN - 0425-1644

VL - 31

SP - 285

EP - 288

JO - Equine Veterinary Journal

JF - Equine Veterinary Journal

IS - 4

ER -

PGFM response to exogenous oxytocin and determination of the half-life of oxytocin in nonpregnant mares

Abstract

Keywords

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