PGFM response to exogenous oxytocin and determination of the half-life of oxytocin in nonpregnant mares

D. L. Paccamonti, J. F. Pycock, M. A.M. Taverne, M. Bevers, G. C. Van Der Weijden, S. Gutjahr, D. Schams, D. Blouin

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37 Scopus citations

Abstract

We investigated the half-life of oxytocin in reproductively normal mares and the prostaglandin response after oxytocin administrations. Mares were given oxytocin, 10 or 25 iu, i.v., on the day of, or 2 days after, ovulation, and frequent jugular blood samples were collected for analysis of oxytocin and Prostaglandin F metabolite (PGFM) by RIA. Neither dose of oxytocin nor day of treatment affected the half-life of the exogenous oxytocin, which was determined to be 6.8 min. A significant increase in PGFM was observed within 6 min of oxytocin administration and peak values were observed within 10 min. PGFM response after oxytocin administration on the day of ovulation appeared elevated compared to the response 2 days after ovulation.

Original languageEnglish
Pages (from-to)285-288
Number of pages4
JournalEquine Veterinary Journal
Volume31
Issue number4
DOIs
StatePublished - Jul 1999

Keywords

  • Horse
  • Mare
  • Oxytocin
  • Prostaglandin
  • Uterus

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