PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery

Raúl Cosialls; Cristina Simó; Salvador Borrós; Vanessa Gómez-Vallejo; Claudia Schmidt; Jordi Llop; Ana B. Cuenca; Angela Casini

doi:10.1002/chem.202202604

PET Imaging of Self-Assembled ¹⁸F-Labelled Pd₂L₄ Metallacages for Anticancer Drug Delivery

Raúl Cosialls
, Cristina Simó
, Salvador Borrós
, Vanessa Gómez-Vallejo
, Claudia Schmidt
, Jordi Llop
, Ana B. Cuenca
, Angela Casini

Chair of Medicinal and Bioinorganic Chemistry

Institut Químic de Sarrià
Biodonostia Health Research Institute-CIBERNED-UPV-EHU
CIC biomaGUNE
Technical University of Munich
Centro de Innovación en Química Avanzada (ORFEO-CINQA)

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of ¹⁸F-labelled [Pd₂L₄]⁴⁺ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.

Original language	English
Article number	e202202604
Journal	Chemistry - A European Journal
Volume	29
Issue number	3
DOIs	https://doi.org/10.1002/chem.202202604
State	Published - 12 Jan 2023

Keywords

PET imaging
ammonium trifluoroborates
cisplatin
drug delivery
metallacages
self-assembly

Access to Document

10.1002/chem.202202604

Cite this

@article{5571ceed4ef14d93890d4735230ff43d,

title = "PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery",

abstract = "To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18F-labelled [Pd2L4]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.",

keywords = "PET imaging, ammonium trifluoroborates, cisplatin, drug delivery, metallacages, self-assembly",

author = "Ra{\'u}l Cosialls and Cristina Sim{\'o} and Salvador Borr{\'o}s and Vanessa G{\'o}mez-Vallejo and Claudia Schmidt and Jordi Llop and Cuenca, \{Ana B.\} and Angela Casini",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.",

year = "2023",

month = jan,

day = "12",

doi = "10.1002/chem.202202604",

language = "English",

volume = "29",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

TY - JOUR

T1 - PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery

AU - Cosialls, Raúl

AU - Simó, Cristina

AU - Borrós, Salvador

AU - Gómez-Vallejo, Vanessa

AU - Schmidt, Claudia

AU - Llop, Jordi

AU - Cuenca, Ana B.

AU - Casini, Angela

PY - 2023/1/12

Y1 - 2023/1/12

N2 - To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18F-labelled [Pd2L4]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.

AB - To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18F-labelled [Pd2L4]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.

KW - PET imaging

KW - ammonium trifluoroborates

KW - cisplatin

KW - drug delivery

KW - metallacages

KW - self-assembly

UR - https://www.scopus.com/pages/publications/85142294018

U2 - 10.1002/chem.202202604

DO - 10.1002/chem.202202604

M3 - Article

C2 - 36239701

AN - SCOPUS:85142294018

SN - 0947-6539

VL - 29

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 3

M1 - e202202604

ER -

PET Imaging of Self-Assembled ¹⁸F-Labelled Pd₂L₄ Metallacages for Anticancer Drug Delivery

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this