PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery

Raúl Cosialls; Cristina Simó; Salvador Borrós; Vanessa Gómez-Vallejo; Claudia Schmidt; Jordi Llop; Ana B. Cuenca; Angela Casini

doi:10.1002/chem.202202604

PET Imaging of Self-Assembled ¹⁸F-Labelled Pd₂L₄ Metallacages for Anticancer Drug Delivery

Raúl Cosialls, Cristina Simó, Salvador Borrós, Vanessa Gómez-Vallejo, Claudia Schmidt, Jordi Llop, Ana B. Cuenca, Angela Casini

Chair of Medicinal and Bioinorganic Chemistry

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of ¹⁸F-labelled [Pd₂L₄]⁴⁺ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.

Original language	English
Article number	e202202604
Journal	Chemistry - A European Journal
Volume	29
Issue number	3
DOIs	https://doi.org/10.1002/chem.202202604
State	Published - 12 Jan 2023

Keywords

PET imaging
ammonium trifluoroborates
cisplatin
drug delivery
metallacages
self-assembly

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10.1002/chem.202202604

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title = "PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery",

abstract = "To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18F-labelled [Pd2L4]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.",

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T1 - PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery

AU - Cosialls, Raúl

AU - Simó, Cristina

AU - Borrós, Salvador

AU - Gómez-Vallejo, Vanessa

AU - Schmidt, Claudia

AU - Llop, Jordi

AU - Cuenca, Ana B.

AU - Casini, Angela

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AB - To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18F-labelled [Pd2L4]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.

KW - PET imaging

KW - ammonium trifluoroborates

KW - cisplatin

KW - drug delivery

KW - metallacages

KW - self-assembly

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JO - Chemistry - A European Journal

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ER -

PET Imaging of Self-Assembled ¹⁸F-Labelled Pd₂L₄ Metallacages for Anticancer Drug Delivery

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