Perspectives on NMR in drug discovery: A technique comes of age

Maurizio Pellecchia; Ivano Bertini; David Cowburn; Claudio Dalvit; Ernest Giralt; Wolfgang Jahnke; Thomas L. James; Steve W. Homans; Horst Kessler; Claudio Luchinat; Bernd Meyer; Hartmut Oschkinat; Jeff Peng; Harald Schwalbe; Gregg Siegal

doi:10.1038/nrd2606

Perspectives on NMR in drug discovery: A technique comes of age

Maurizio Pellecchia, Ivano Bertini, David Cowburn, Claudio Dalvit, Ernest Giralt, Wolfgang Jahnke, Thomas L. James, Steve W. Homans, Horst Kessler, Claudio Luchinat, Bernd Meyer, Hartmut Oschkinat, Jeff Peng, Harald Schwalbe, Gregg Siegal

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Abstract

In the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. In this Perspective, we highlight some of the major applications of NMR in drug discovery, focusing on hit and lead generation, and provide a critical analysis of its current and potential utility.

Original language	English
Pages (from-to)	738-745
Number of pages	8
Journal	Nature Reviews Drug Discovery
Volume	7
Issue number	9
DOIs	https://doi.org/10.1038/nrd2606
State	Published - 1 Sep 2008

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title = "Perspectives on NMR in drug discovery: A technique comes of age",

abstract = "In the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. In this Perspective, we highlight some of the major applications of NMR in drug discovery, focusing on hit and lead generation, and provide a critical analysis of its current and potential utility.",

author = "Maurizio Pellecchia and Ivano Bertini and David Cowburn and Claudio Dalvit and Ernest Giralt and Wolfgang Jahnke and James, {Thomas L.} and Homans, {Steve W.} and Horst Kessler and Claudio Luchinat and Bernd Meyer and Hartmut Oschkinat and Jeff Peng and Harald Schwalbe and Gregg Siegal",

note = "Funding Information: This article is based on a document drafted by I. B., C. L. and M. P., during the workshop {\textquoteleft}Perspectives of NMR in Drug Discovery{\textquoteright} held in Florence April 2007. Financial support by the NMR-Life Coordination Action LSHG-CT-2005-018,758, by Ente CR Firenze and by MCYT-FEDER (Bio2005-00295) is gratefully acknowledged. We thank M. Fragai and C. Lipinski for suggestions and comments. We also thank L. Slivka for careful assistance in the preparation of the manuscript.",

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T2 - A technique comes of age

AU - Pellecchia, Maurizio

AU - Bertini, Ivano

AU - Cowburn, David

AU - Dalvit, Claudio

AU - Giralt, Ernest

AU - Jahnke, Wolfgang

AU - James, Thomas L.

AU - Homans, Steve W.

AU - Kessler, Horst

AU - Luchinat, Claudio

AU - Meyer, Bernd

AU - Oschkinat, Hartmut

AU - Peng, Jeff

AU - Schwalbe, Harald

AU - Siegal, Gregg

N1 - Funding Information: This article is based on a document drafted by I. B., C. L. and M. P., during the workshop ‘Perspectives of NMR in Drug Discovery’ held in Florence April 2007. Financial support by the NMR-Life Coordination Action LSHG-CT-2005-018,758, by Ente CR Firenze and by MCYT-FEDER (Bio2005-00295) is gratefully acknowledged. We thank M. Fragai and C. Lipinski for suggestions and comments. We also thank L. Slivka for careful assistance in the preparation of the manuscript.

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Perspectives on NMR in drug discovery: A technique comes of age

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