Perspectives on clinical magnetic particle imaging

Jörn Borgert; Joachim D. Schmidt; Ingo Schmale; Claas Bontus; Bernhard Gleich; Bernd David; Jürgen Weizenecker; Jonas Jockram; Christian Lauruschkat; Oliver Mende; Mathias Heinrich; Aleksi Halkola; Jörn Bergmann; Oliver Woywode; Jürgen Rahmer

doi:10.1515/bmt-2012-0064

Perspectives on clinical magnetic particle imaging

Jörn Borgert, Joachim D. Schmidt, Ingo Schmale, Claas Bontus, Bernhard Gleich, Bernd David, Jürgen Weizenecker, Jonas Jockram, Christian Lauruschkat, Oliver Mende, Mathias Heinrich, Aleksi Halkola, Jörn Bergmann, Oliver Woywode, Jürgen Rahmer

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

After realizing the worlds' first preclinical magnetic particle imaging (MPI) demonstrator, Philips is now realizing the worlds' first whole-body clinical prototype to prove the feasibility of MPI for clinical imaging. After a brief introduction of the basic MPI imaging process, this contribution presents an overview on the determining factors for key properties, i.e., spatial resolution, acquisition speed, sensitivity, and quantitativeness, and how these properties are influenced by scaling up from preclinical to clinical instrumentation. Furthermore, it is discussed how this scale up affects the physiological compatibility of the method as well as hardware parameters such as power requirements for drive field generation, selection and focus field generation, and the design of the receive chain of the MPI device.

Original language	English
Pages (from-to)	551-556
Number of pages	6
Journal	Biomedizinische Technik
Volume	58
Issue number	6
DOIs	https://doi.org/10.1515/bmt-2012-0064
State	Published - 1 Dec 2013
Externally published	Yes

Keywords

magnetic particle imaging
medical imaging
nanoparticles

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10.1515/bmt-2012-0064

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title = "Perspectives on clinical magnetic particle imaging",

abstract = "After realizing the worlds' first preclinical magnetic particle imaging (MPI) demonstrator, Philips is now realizing the worlds' first whole-body clinical prototype to prove the feasibility of MPI for clinical imaging. After a brief introduction of the basic MPI imaging process, this contribution presents an overview on the determining factors for key properties, i.e., spatial resolution, acquisition speed, sensitivity, and quantitativeness, and how these properties are influenced by scaling up from preclinical to clinical instrumentation. Furthermore, it is discussed how this scale up affects the physiological compatibility of the method as well as hardware parameters such as power requirements for drive field generation, selection and focus field generation, and the design of the receive chain of the MPI device.",

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AU - Borgert, Jörn

AU - Schmidt, Joachim D.

AU - Schmale, Ingo

AU - Bontus, Claas

AU - Gleich, Bernhard

AU - David, Bernd

AU - Weizenecker, Jürgen

AU - Jockram, Jonas

AU - Lauruschkat, Christian

AU - Mende, Oliver

AU - Heinrich, Mathias

AU - Halkola, Aleksi

AU - Bergmann, Jörn

AU - Woywode, Oliver

AU - Rahmer, Jürgen

PY - 2013/12/1

Y1 - 2013/12/1

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AB - After realizing the worlds' first preclinical magnetic particle imaging (MPI) demonstrator, Philips is now realizing the worlds' first whole-body clinical prototype to prove the feasibility of MPI for clinical imaging. After a brief introduction of the basic MPI imaging process, this contribution presents an overview on the determining factors for key properties, i.e., spatial resolution, acquisition speed, sensitivity, and quantitativeness, and how these properties are influenced by scaling up from preclinical to clinical instrumentation. Furthermore, it is discussed how this scale up affects the physiological compatibility of the method as well as hardware parameters such as power requirements for drive field generation, selection and focus field generation, and the design of the receive chain of the MPI device.

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KW - medical imaging

KW - nanoparticles

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Perspectives on clinical magnetic particle imaging

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Keywords

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