Perspective of αvβ6-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions

Katja Steiger; Anna Melissa Schlitter; Wilko Weichert; Irene Esposito; Hans Jürgen Wester; Johannes Notni

doi:10.1177/1536012117709384

Perspective of α_vβ₆-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions

Katja Steiger
, Anna Melissa Schlitter
, Wilko Weichert
, Irene Esposito
, Hans Jürgen Wester
, Johannes Notni

Technical University of Munich
German Cancer Research Center
Medical Faculty and University Hospital Düsseldorf

Research output: Contribution to journal › Comment/debate

33 Scopus citations

Abstract

ß₆-integrin immunohistochemistry analysis of a large number of pancreatic ductal adenocarcinoma (PDAC, 383 primary tumors, 7 lymph node, and 8 distant metastases) and 34 pancreatic intraepithelial neoplasia (PanIN) specimens revealed a high prevalence of α_vß₆-integrin expression in PDAC primaries (88%) and in almost all metastases, as well as in PanIN (57%). These findings underscore the high potential of a novel α_vß₆-integrin targeting positron emission tomography (PET) radiopharmaceutical, Ga-68-Avebehexin, for early diagnosis of pancreatic cancer.

Original language	English
Journal	Molecular Imaging
Volume	16
DOIs	https://doi.org/10.1177/1536012117709384
State	Published - 11 Dec 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer detection imaging
cancer imaging
clinical translation of novel oncologic radiotracers
immunohistochemistry
integrin

Access to Document

10.1177/1536012117709384

Cite this

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title = "Perspective of αvβ6-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions",

abstract = "{\ss}6-integrin immunohistochemistry analysis of a large number of pancreatic ductal adenocarcinoma (PDAC, 383 primary tumors, 7 lymph node, and 8 distant metastases) and 34 pancreatic intraepithelial neoplasia (PanIN) specimens revealed a high prevalence of αv{\ss}6-integrin expression in PDAC primaries (88\%) and in almost all metastases, as well as in PanIN (57\%). These findings underscore the high potential of a novel αv{\ss}6-integrin targeting positron emission tomography (PET) radiopharmaceutical, Ga-68-Avebehexin, for early diagnosis of pancreatic cancer.",

keywords = "cancer detection imaging, cancer imaging, clinical translation of novel oncologic radiotracers, immunohistochemistry, integrin",

author = "Katja Steiger and Schlitter, \{Anna Melissa\} and Wilko Weichert and Irene Esposito and Wester, \{Hans J{\"u}rgen\} and Johannes Notni",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2017.",

year = "2017",

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doi = "10.1177/1536012117709384",

language = "English",

volume = "16",

journal = "Molecular Imaging",

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T1 - Perspective of αvβ6-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions

AU - Steiger, Katja

AU - Schlitter, Anna Melissa

AU - Weichert, Wilko

AU - Esposito, Irene

AU - Wester, Hans Jürgen

AU - Notni, Johannes

N1 - Publisher Copyright: © The Author(s) 2017.

PY - 2017/12/11

Y1 - 2017/12/11

N2 - ß6-integrin immunohistochemistry analysis of a large number of pancreatic ductal adenocarcinoma (PDAC, 383 primary tumors, 7 lymph node, and 8 distant metastases) and 34 pancreatic intraepithelial neoplasia (PanIN) specimens revealed a high prevalence of αvß6-integrin expression in PDAC primaries (88%) and in almost all metastases, as well as in PanIN (57%). These findings underscore the high potential of a novel αvß6-integrin targeting positron emission tomography (PET) radiopharmaceutical, Ga-68-Avebehexin, for early diagnosis of pancreatic cancer.

AB - ß6-integrin immunohistochemistry analysis of a large number of pancreatic ductal adenocarcinoma (PDAC, 383 primary tumors, 7 lymph node, and 8 distant metastases) and 34 pancreatic intraepithelial neoplasia (PanIN) specimens revealed a high prevalence of αvß6-integrin expression in PDAC primaries (88%) and in almost all metastases, as well as in PanIN (57%). These findings underscore the high potential of a novel αvß6-integrin targeting positron emission tomography (PET) radiopharmaceutical, Ga-68-Avebehexin, for early diagnosis of pancreatic cancer.

KW - cancer detection imaging

KW - cancer imaging

KW - clinical translation of novel oncologic radiotracers

KW - immunohistochemistry

KW - integrin

UR - https://www.scopus.com/pages/publications/85028944633

U2 - 10.1177/1536012117709384

DO - 10.1177/1536012117709384

M3 - Comment/debate

C2 - 28627323

AN - SCOPUS:85028944633

SN - 1535-3508

VL - 16

JO - Molecular Imaging

JF - Molecular Imaging

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