Perspective of αvβ6-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions

Katja Steiger, Anna Melissa Schlitter, Wilko Weichert, Irene Esposito, Hans Jürgen Wester, Johannes Notni

Research output: Contribution to journalComment/debate

25 Scopus citations

Abstract

ß6-integrin immunohistochemistry analysis of a large number of pancreatic ductal adenocarcinoma (PDAC, 383 primary tumors, 7 lymph node, and 8 distant metastases) and 34 pancreatic intraepithelial neoplasia (PanIN) specimens revealed a high prevalence of αvß6-integrin expression in PDAC primaries (88%) and in almost all metastases, as well as in PanIN (57%). These findings underscore the high potential of a novel αvß6-integrin targeting positron emission tomography (PET) radiopharmaceutical, Ga-68-Avebehexin, for early diagnosis of pancreatic cancer.

Original languageEnglish
JournalMolecular Imaging
Volume16
DOIs
StatePublished - 11 Dec 2017

Keywords

  • cancer detection imaging
  • cancer imaging
  • clinical translation of novel oncologic radiotracers
  • immunohistochemistry
  • integrin

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