Perspective of αvβ6-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions

Katja Steiger; Anna Melissa Schlitter; Wilko Weichert; Irene Esposito; Hans Jürgen Wester; Johannes Notni

doi:10.1177/1536012117709384

Perspective of α_vβ₆-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions

Katja Steiger, Anna Melissa Schlitter, Wilko Weichert, Irene Esposito, Hans Jürgen Wester, Johannes Notni

Research output: Contribution to journal › Comment/debate

27 Scopus citations

Abstract

ß₆-integrin immunohistochemistry analysis of a large number of pancreatic ductal adenocarcinoma (PDAC, 383 primary tumors, 7 lymph node, and 8 distant metastases) and 34 pancreatic intraepithelial neoplasia (PanIN) specimens revealed a high prevalence of α_vß₆-integrin expression in PDAC primaries (88%) and in almost all metastases, as well as in PanIN (57%). These findings underscore the high potential of a novel α_vß₆-integrin targeting positron emission tomography (PET) radiopharmaceutical, Ga-68-Avebehexin, for early diagnosis of pancreatic cancer.

Original language	English
Journal	Molecular Imaging
Volume	16
DOIs	https://doi.org/10.1177/1536012117709384
State	Published - 11 Dec 2017

Keywords

cancer detection imaging
cancer imaging
clinical translation of novel oncologic radiotracers
immunohistochemistry
integrin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/1536012117709384

Cite this

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title = "Perspective of αvβ6-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions",

abstract = "{\ss}6-integrin immunohistochemistry analysis of a large number of pancreatic ductal adenocarcinoma (PDAC, 383 primary tumors, 7 lymph node, and 8 distant metastases) and 34 pancreatic intraepithelial neoplasia (PanIN) specimens revealed a high prevalence of αv{\ss}6-integrin expression in PDAC primaries (88%) and in almost all metastases, as well as in PanIN (57%). These findings underscore the high potential of a novel αv{\ss}6-integrin targeting positron emission tomography (PET) radiopharmaceutical, Ga-68-Avebehexin, for early diagnosis of pancreatic cancer.",

keywords = "cancer detection imaging, cancer imaging, clinical translation of novel oncologic radiotracers, immunohistochemistry, integrin",

author = "Katja Steiger and Schlitter, {Anna Melissa} and Wilko Weichert and Irene Esposito and Wester, {Hans J{\"u}rgen} and Johannes Notni",

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T1 - Perspective of αvβ6-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions

AU - Steiger, Katja

AU - Schlitter, Anna Melissa

AU - Weichert, Wilko

AU - Esposito, Irene

AU - Wester, Hans Jürgen

AU - Notni, Johannes

N1 - Publisher Copyright: © The Author(s) 2017.

PY - 2017/12/11

Y1 - 2017/12/11

N2 - ß6-integrin immunohistochemistry analysis of a large number of pancreatic ductal adenocarcinoma (PDAC, 383 primary tumors, 7 lymph node, and 8 distant metastases) and 34 pancreatic intraepithelial neoplasia (PanIN) specimens revealed a high prevalence of αvß6-integrin expression in PDAC primaries (88%) and in almost all metastases, as well as in PanIN (57%). These findings underscore the high potential of a novel αvß6-integrin targeting positron emission tomography (PET) radiopharmaceutical, Ga-68-Avebehexin, for early diagnosis of pancreatic cancer.

AB - ß6-integrin immunohistochemistry analysis of a large number of pancreatic ductal adenocarcinoma (PDAC, 383 primary tumors, 7 lymph node, and 8 distant metastases) and 34 pancreatic intraepithelial neoplasia (PanIN) specimens revealed a high prevalence of αvß6-integrin expression in PDAC primaries (88%) and in almost all metastases, as well as in PanIN (57%). These findings underscore the high potential of a novel αvß6-integrin targeting positron emission tomography (PET) radiopharmaceutical, Ga-68-Avebehexin, for early diagnosis of pancreatic cancer.

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KW - cancer imaging

KW - clinical translation of novel oncologic radiotracers

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