Personalizing KRAS-mutant allele–speciﬁc therapies

Chiara Falcomatà; Günter Schneider; Dieter Saur

doi:10.1158/2159-8290.CD-19-1261

Personalizing KRAS-mutant allele–speciﬁc therapies

Chiara Falcomatà, Günter Schneider, Dieter Saur

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

KRAS^G12R mutations occur almost exclusively in pancreatic ductal adenocarcinoma. The results of a study that reveals specific differences in KRAS downstream signaling and metabolic rewiring of pancreatic cancer cells harboring KRAS^G12R mutations promise to improve our possibilities to better stratify patients for individualized therapies.

Original language	English
Pages (from-to)	23-25
Number of pages	3
Journal	Cancer Discovery
Volume	10
Issue number	1
DOIs	https://doi.org/10.1158/2159-8290.CD-19-1261
State	Published - Jan 2020
Externally published	Yes

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10.1158/2159-8290.CD-19-1261

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@article{90b25d284a4d4e609326245a2b7688d5,

title = "Personalizing KRAS-mutant allele–speciﬁc therapies",

abstract = "KRASG12R mutations occur almost exclusively in pancreatic ductal adenocarcinoma. The results of a study that reveals specific differences in KRAS downstream signaling and metabolic rewiring of pancreatic cancer cells harboring KRASG12R mutations promise to improve our possibilities to better stratify patients for individualized therapies.",

author = "Chiara Falcomat{\`a} and G{\"u}nter Schneider and Dieter Saur",

note = "Publisher Copyright: {\textcopyright} 2020 American Association for Cancer Research.",

year = "2020",

month = jan,

doi = "10.1158/2159-8290.CD-19-1261",

language = "English",

volume = "10",

pages = "23--25",

journal = "Cancer Discovery",

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publisher = "American Association for Cancer Research Inc.",

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T1 - Personalizing KRAS-mutant allele–speciﬁc therapies

AU - Falcomatà, Chiara

AU - Schneider, Günter

AU - Saur, Dieter

PY - 2020/1

Y1 - 2020/1

N2 - KRASG12R mutations occur almost exclusively in pancreatic ductal adenocarcinoma. The results of a study that reveals specific differences in KRAS downstream signaling and metabolic rewiring of pancreatic cancer cells harboring KRASG12R mutations promise to improve our possibilities to better stratify patients for individualized therapies.

AB - KRASG12R mutations occur almost exclusively in pancreatic ductal adenocarcinoma. The results of a study that reveals specific differences in KRAS downstream signaling and metabolic rewiring of pancreatic cancer cells harboring KRASG12R mutations promise to improve our possibilities to better stratify patients for individualized therapies.

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U2 - 10.1158/2159-8290.CD-19-1261

DO - 10.1158/2159-8290.CD-19-1261

M3 - Article

C2 - 31919121

AN - SCOPUS:85077674285

SN - 2159-8274

VL - 10

SP - 23

EP - 25

JO - Cancer Discovery

JF - Cancer Discovery

IS - 1

ER -

Personalizing KRAS-mutant allele–speciﬁc therapies

Abstract

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