TY - JOUR
T1 - Personalisierte Medizin in der Onkologie
AU - Lörsch, Alisa Martina
AU - Jung, Johannes
AU - Lange, Sebastian
AU - Pfarr, Nicole
AU - Mogler, Carolin
AU - Illert, Anna Lena
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2024.
PY - 2024/5
Y1 - 2024/5
N2 - Due to the considerable technological progress in molecular and genetic diagnostics as well as increasing insights into the molecular pathogenesis of diseases, there has been a fundamental paradigm shift in the past two decades from a “one-size-fits-all approach” to personalized, molecularly informed treatment strategies. Personalized medicine or precision medicine focuses on the genetic, physiological, molecular, and biochemical differences between individuals and considers their effects on the development, prevention, and treatment of diseases. As a pioneer of personalized medicine, the field of oncology is particularly noteworthy, where personalized diagnostics and treatment have led to lasting change in the treatment of cancer patients in recent years. In this article, the significant change towards personalized treatment concepts, especially in the field of personalized oncology, will be discussed and examined in more detail.
AB - Due to the considerable technological progress in molecular and genetic diagnostics as well as increasing insights into the molecular pathogenesis of diseases, there has been a fundamental paradigm shift in the past two decades from a “one-size-fits-all approach” to personalized, molecularly informed treatment strategies. Personalized medicine or precision medicine focuses on the genetic, physiological, molecular, and biochemical differences between individuals and considers their effects on the development, prevention, and treatment of diseases. As a pioneer of personalized medicine, the field of oncology is particularly noteworthy, where personalized diagnostics and treatment have led to lasting change in the treatment of cancer patients in recent years. In this article, the significant change towards personalized treatment concepts, especially in the field of personalized oncology, will be discussed and examined in more detail.
KW - Biomarker
KW - Next-generation sequencing
KW - Personalized medicine
KW - Targeted therapy
KW - Tumor-agnostic therapy
UR - http://www.scopus.com/inward/record.url?scp=85189329115&partnerID=8YFLogxK
U2 - 10.1007/s00292-024-01315-8
DO - 10.1007/s00292-024-01315-8
M3 - Artikel
C2 - 38568256
AN - SCOPUS:85189329115
SN - 2731-7188
VL - 45
SP - 180
EP - 189
JO - Pathologie
JF - Pathologie
IS - 3
ER -
