TY - JOUR
T1 - Persistent organic pollutants and the incidence of type 2 diabetes in the CARLA and KORA cohort studies
AU - Wolf, Kathrin
AU - Bongaerts, Brenda W.C.
AU - Schneider, Alexandra
AU - Huth, Cornelia
AU - Meisinger, Christa
AU - Peters, Annette
AU - Schneider, Andrea
AU - Wittsiepe, Jürgen
AU - Schramm, Karl Werner
AU - Greiser, Karin Halina
AU - Hartwig, Saskia
AU - Kluttig, Alexander
AU - Rathmann, Wolfgang
N1 - Publisher Copyright:
© 2019
PY - 2019/8
Y1 - 2019/8
N2 - Background: Associations between several persistent organic pollutants (POPs)and type 2 diabetes have been found in humans, but the relationship has rarely been investigated in the general population. The current nested case-control study examined internal exposure to polychlorinated biphenyls (PCB)and pesticides and the incidence of type 2 diabetes among participants of two population-based German cohort studies. Methods: We retrospectively selected 132 incident cases of type 2 diabetes and 264 age- and sex-matched controls from the CARdiovascular Living and Aging in Halle (CARLA)study (2002–2006, East Germany)and the Cooperative Health Research in the Region of Augsburg (KORA)study (1999–2001, South Germany)based on diabetes status at follow-up examinations in 2007–2010 and 2006–08, respectively (60% male, mean age 63 and 54 years). We assessed the association between baseline POP concentrations and incident diabetes by conditional logistic regression adjusted for cohort, BMI, cholesterol, alcohol, smoking, physical activity, and parental diabetes. Additionally, we examined effect modification by sex, obesity, parental diabetes and cohort. Results: In both cohorts, diabetes cases showed a higher BMI, a higher frequency of parental diabetes, and higher levels of POPs. We observed an increased chance for incident diabetes for PCB-138 and PCB-153 with an odds ratio (OR)of 1.50 (95%CI: 1.07–2.11)and 1.53 (1.15–2.04)per interquartile range increase in the respective POP. In addition, explorative results suggested higher OR for women and non-obese participants. Conclusions: Our results add to the evidence on diabetogenic effects of POPs in the general population, and warrant both policies to prevent human exposure to POPs and additional research on the adverse effects of more complex chemical mixtures.
AB - Background: Associations between several persistent organic pollutants (POPs)and type 2 diabetes have been found in humans, but the relationship has rarely been investigated in the general population. The current nested case-control study examined internal exposure to polychlorinated biphenyls (PCB)and pesticides and the incidence of type 2 diabetes among participants of two population-based German cohort studies. Methods: We retrospectively selected 132 incident cases of type 2 diabetes and 264 age- and sex-matched controls from the CARdiovascular Living and Aging in Halle (CARLA)study (2002–2006, East Germany)and the Cooperative Health Research in the Region of Augsburg (KORA)study (1999–2001, South Germany)based on diabetes status at follow-up examinations in 2007–2010 and 2006–08, respectively (60% male, mean age 63 and 54 years). We assessed the association between baseline POP concentrations and incident diabetes by conditional logistic regression adjusted for cohort, BMI, cholesterol, alcohol, smoking, physical activity, and parental diabetes. Additionally, we examined effect modification by sex, obesity, parental diabetes and cohort. Results: In both cohorts, diabetes cases showed a higher BMI, a higher frequency of parental diabetes, and higher levels of POPs. We observed an increased chance for incident diabetes for PCB-138 and PCB-153 with an odds ratio (OR)of 1.50 (95%CI: 1.07–2.11)and 1.53 (1.15–2.04)per interquartile range increase in the respective POP. In addition, explorative results suggested higher OR for women and non-obese participants. Conclusions: Our results add to the evidence on diabetogenic effects of POPs in the general population, and warrant both policies to prevent human exposure to POPs and additional research on the adverse effects of more complex chemical mixtures.
KW - Case-control study
KW - Environmental contaminates
KW - Epidemiology
KW - Incidence
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85066084984&partnerID=8YFLogxK
U2 - 10.1016/j.envint.2019.05.030
DO - 10.1016/j.envint.2019.05.030
M3 - Article
C2 - 31132656
AN - SCOPUS:85066084984
SN - 0160-4120
VL - 129
SP - 221
EP - 228
JO - Environment International
JF - Environment International
ER -