Peroxiporins: Redox Signal Mediators In and Between Cells

Iria Medraño-Fernandez, Gerd Patrick Bienert, Roberto Sitia

Research output: Book/ReportBookpeer-review

Abstract

To produce energy, aerobic organisms transform oxygen molecules into water. This reductive mechanism yields toxic radical intermediates, collectively known as reactive oxygen species (ROS). Paradoxically, these physiological processes entail the production of potentially damaging species. Evolution has turned this apparent disadvantage into an opportunity for transmitting information. As a result, redox signaling within the cell is an efficient exquisitely organized process. A key element for its regulation is the physical separation of sources and targets into different cell compartments. Peroxiporins, H2O2 transporting proteins spanning biological membranes, distribute the signal from emitters to receptors. Thus, these channels are strategically situated in the thin line between life and death, guaranteeing adequate but safe signaling.

Original languageEnglish
PublisherCRC Press
Number of pages228
ISBN (Electronic)9781000927788
ISBN (Print)9780367745899
DOIs
StatePublished - 1 Jan 2023

Keywords

  • Discusses the cartography of redox signaling in crowded cells
  • Highlights recent findings, outstanding controversies and open questions
  • Includes lavish illustrations and comprehensive images to facilitate teaching
  • Provides a brief history of the discovery and characterization of peroxiporins
  • Reviews key findings on hydrogen peroxide transport across biological membranes

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