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PERK activation mitigates tau pathology in vitro and in vivo
Julius Bruch
, Hong Xu
, Thomas W. Rösler
, Anderson De Andrade
, Peer Hendrik Kuhn
,
Stefan F. Lichtenthaler
, Thomas Arzberger
, Konstanze F. Winklhofer
, Ulrich Müller
,
Günter U. Höglinger
Institute of Laboratory Medicine
Department of Neurology
German Center for Neurodegenerative Diseases (DZNE)
Technical University of Munich
Munich Cluster for Systems Neurology (SyNergy)
University of Munich
Max-Planck-lnstitut für Kohlenforschung
Justus-Liebig-Universität Gießen
Research output
:
Contribution to journal
›
Article
›
peer-review
103
Scopus citations
Overview
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Keyphrases
Tau Pathology
100%
Progressive Supranuclear Palsy
100%
Tauopathy
75%
Tauopathy Model
50%
P301S
50%
Beneficial Effects
25%
Dendritic Spines
25%
Cell Viability
25%
Detrimental Effects
25%
Functional Mechanism
25%
Motoneuron
25%
Endoplasmic Reticulum
25%
Overexpression
25%
Overexpressing
25%
Conformational Change
25%
Brain Model
25%
Memory Function
25%
Tau Phosphorylation
25%
Locomotor Function
25%
Human Neurons
25%
Annonacin
25%
Four-repeat tau
25%
CCT020312
25%
Tau Transgenic Mouse
25%
Tau Isoforms
25%
EIF2a
25%
PERK Signaling
25%
Environmental Neurotoxin
25%
In Vivo Applications
25%
Neuroscience
Tauopathy
100%
Progressive Supranuclear Palsy
80%
Dendritic Spine
20%
In Vivo
20%
Kinase
20%
In Vitro
20%
Cell Viability
20%
Annonacin
20%
Neurotoxin
20%
Endoplasmic Reticulum
20%
Biochemistry, Genetics and Molecular Biology
Tau
100%
RNA
12%
Isoform
12%
Conformational Change
12%
Wild Type
12%
Neurotoxin
12%
Transgenic Mouse
12%
Cell Viability
12%
Dendritic Spine
12%
Phosphotransferase
12%
Kinase
12%