Perioperative neurocognitive functions in patients with neuroepithelial intracranial tumors

Stefanie Bette, Corinna V. Gradtke, Jasmin Hernandez Cammardella, Jennifer Albertshauser, Benedikt Wiestler, Melanie Barz, Bernhard Meyer, Claus Zimmer, Yu Mi Ryang, Florian Ringel, Jens Gempt

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Purpose: This study aimed to assess perioperative neurocognitive functions in patients with surgery for intracranial neuroepithelial tumors. Methods: Seventy-one patients [38 male, 33 female, mean age 47.2 years (range 18 to 81)] with surgery for an intracranial neuroepithelial tumor were included in this prospective single-center study. Mini-mental status examination (MMSE) and extensive neurocognitive testing (divided into the categories attention, memory, and executive functions and adjusted for age, sex, and education) were performed pre-(t0) and early postoperatively (t1). Part of the patient cohort (n = 32) also underwent neurocognitive testing during follow-up (t2). The Karnofsky Performance Status Scale (KPS) was used to assess patients’ functional independence. Patients’ quality of life was recorded by the Short Form 36 (SF 36) pre- and postoperatively in a part of the patient cohort. Pre- and postoperative comparisons were performed using the Wilcoxon-test for paired samples. Post hoc Bonferroni correction was performed to adjust for multiple testing. To assess the influence of risk factors on neurocognitive functions, Spearman correlations and the chi-squared test were performed. Subgroup analyses for patients with low-grade and high-grade tumors were performed. Results: Postoperative deterioration was observed in 5 of 39 subtests of extensive neurocognitive testing in all 3 categories, whereas no improvement was shown. Patients with WHO Grade I tumors showed no deterioration of cognitive functions. Patients with WHO Grade II and III tumors showed significantly worse results in the executive functions category patients with WHO Grade IV tumors showed deterioration in the attention category. Significantly worse functional independence was recorded postoperatively and during follow-up (P < 0.001). Patients reported poorer physical health (SF 36, P = 0.001) at t1, whereas mental health did not differ significantly (P = 0.480). Risk factors for postoperative deterioration of cognition are low KPS scores, postoperative radiotherapy and tumor location in the temporal lobe. Conclusions: After surgery on an intracranial neuroepithelial tumor, early postoperative deterioration of neurocognitive functions, functional independence and physical health occur. Similar results were also shown during follow-up suggesting that these effects are not only due to postoperative systemic factors or fatigue. This knowledge might improve perioperative surveillance of neurocognitive functions.

Original languageEnglish
Pages (from-to)77-89
Number of pages13
JournalJournal of Neuro-Oncology
Volume147
Issue number1
DOIs
StatePublished - 1 Mar 2020
Externally publishedYes

Keywords

  • Attention
  • Executive functions
  • Memory
  • Neurocognition
  • Neuroepithelial tumors
  • Surgery

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