TY - JOUR
T1 - Perfusion abnormalities in mild cognitive impairment and mild dementia in Alzheimer's disease measured by pulsed arterial spin labeling MRI
AU - Alexopoulos, Panagiotis
AU - Sorg, Christian
AU - Förschler, Annette
AU - Grimmer, Timo
AU - Skokou, Maria
AU - Wohlschläger, Afra
AU - Perneczky, Robert
AU - Zimmer, Claus
AU - Kurz, Alexander
AU - Preibisch, Christine
N1 - Funding Information:
Acknowledgments We would like to thank all the healthy and diseased volunteers who participated in this study. AMW is supported by the German Federal Ministry of Education and Research, BMBF grant 01EV0710.
PY - 2012/2
Y1 - 2012/2
N2 - Alzheimer's disease (AD) and mild cognitive impairment (MCI), the transitional clinical stage between cognition in normal aging and dementia, have been linked to abnormalities in brain perfusion. Pulsed arterial spin labeling (PASL) is a magnetic resonance imaging (MRI) technique for evaluating brain perfusion. The present study aimed to determine regional perfusion abnormalities in 19 patients with mild dementia in AD and 24 patients with MCI as compared to 24 cognitively healthy elderly controls using PASL. In line with nuclear imaging methods, lower perfusion in patients with MCI and AD was found mainly in the parietal lobe, but also in angular and middle temporal areas as well as in the left middle occipital lobe and precuneus. Our data imply that PASL may be a valuable instrument for investigating perfusion changes in the transition from normal aging to dementia and indicate that it might become an alternative to nuclear imaging techniques in AD diagnostics.
AB - Alzheimer's disease (AD) and mild cognitive impairment (MCI), the transitional clinical stage between cognition in normal aging and dementia, have been linked to abnormalities in brain perfusion. Pulsed arterial spin labeling (PASL) is a magnetic resonance imaging (MRI) technique for evaluating brain perfusion. The present study aimed to determine regional perfusion abnormalities in 19 patients with mild dementia in AD and 24 patients with MCI as compared to 24 cognitively healthy elderly controls using PASL. In line with nuclear imaging methods, lower perfusion in patients with MCI and AD was found mainly in the parietal lobe, but also in angular and middle temporal areas as well as in the left middle occipital lobe and precuneus. Our data imply that PASL may be a valuable instrument for investigating perfusion changes in the transition from normal aging to dementia and indicate that it might become an alternative to nuclear imaging techniques in AD diagnostics.
KW - Alzheimer's disease
KW - Cerebral blood flow (CBF)
KW - Mild cognitive impairment
KW - Pulsed arterial spin labeling (PASL)
UR - http://www.scopus.com/inward/record.url?scp=84861693115&partnerID=8YFLogxK
U2 - 10.1007/s00406-011-0226-2
DO - 10.1007/s00406-011-0226-2
M3 - Article
C2 - 21786091
AN - SCOPUS:84861693115
SN - 0940-1334
VL - 262
SP - 69
EP - 77
JO - European Archives of Psychiatry and Clinical Neuroscience
JF - European Archives of Psychiatry and Clinical Neuroscience
IS - 1
ER -