Performance Limitations in Heart Transplant Recipients

Wesley J. Tucker; Rhys I. Beaudry; T. Jake Samuel; Michael D. Nelson; Martin Halle; Aaron L. Baggish; Mark J. Haykowsky

doi:10.1249/JES.0000000000000149

Performance Limitations in Heart Transplant Recipients

Wesley J. Tucker, Rhys I. Beaudry, T. Jake Samuel, Michael D. Nelson, Martin Halle, Aaron L. Baggish, Mark J. Haykowsky

Chair of Preventive Sports Medicine and Sports Cardiology

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

We hypothesize that the reduced peak aerobic power (peak VO₂) after heart transplantation is due to impaired cardiovascular and skeletal muscle function, and its improvement with short-term (≤1 yr) exercise training is primarily due to favorable skeletal muscle adaptations. Furthermore, the increased peak VO₂ with long-term (>2 yr) training is primarily mediated by cardiac (sympathetic) reinnervation.

Original language	English
Pages (from-to)	144-151
Number of pages	8
Journal	Exercise and Sport Sciences Reviews
Volume	46
Issue number	3
DOIs	https://doi.org/10.1249/JES.0000000000000149
State	Published - 1 Jul 2018

Keywords

cardiac reinnervation
cardiovascular function
exercise training
peak oxygen uptake
skeletal muscle function

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10.1249/JES.0000000000000149

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title = "Performance Limitations in Heart Transplant Recipients",

abstract = "We hypothesize that the reduced peak aerobic power (peak VO2) after heart transplantation is due to impaired cardiovascular and skeletal muscle function, and its improvement with short-term (≤1 yr) exercise training is primarily due to favorable skeletal muscle adaptations. Furthermore, the increased peak VO2 with long-term (>2 yr) training is primarily mediated by cardiac (sympathetic) reinnervation.",

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AU - Beaudry, Rhys I.

AU - Samuel, T. Jake

AU - Nelson, Michael D.

AU - Halle, Martin

AU - Baggish, Aaron L.

AU - Haykowsky, Mark J.

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AB - We hypothesize that the reduced peak aerobic power (peak VO2) after heart transplantation is due to impaired cardiovascular and skeletal muscle function, and its improvement with short-term (≤1 yr) exercise training is primarily due to favorable skeletal muscle adaptations. Furthermore, the increased peak VO2 with long-term (>2 yr) training is primarily mediated by cardiac (sympathetic) reinnervation.

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KW - cardiovascular function

KW - exercise training

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KW - skeletal muscle function

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Performance Limitations in Heart Transplant Recipients

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Keywords

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