Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

Markus Lauerer; Matthias Bussas; Viola Pongratz; Achim Berthele; Jan S. Kirschke; Benedikt Wiestler; Claus Zimmer; Bernhard Hemmer; Mark Mühlau

doi:10.1002/acn3.51700

Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

Markus Lauerer, Matthias Bussas, Viola Pongratz, Achim Berthele, Jan S. Kirschke, Benedikt Wiestler, Claus Zimmer, Bernhard Hemmer, Mark Mühlau

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Brain atrophy in multiple sclerosis (MS), as measured by percentage brain volume change (PBVC) from brain magnetic resonance imaging (MRI), has been established as an outcome parameter in clinical trials. It is unknown to what extent volume changes within different brain tissue compartments contribute to PBVC. We analyzed pairs of MRI scans (at least 6 months apart) in 600 patients with relapsing–remitting MS. Multiple regression revealed that PBVC mainly reflects volume loss of white and cortical gray matter, while deep gray matter and white matter lesions were less represented. Our findings aid the interpretation of PBVC changes in MS.

Original language	English
Pages (from-to)	130-135
Number of pages	6
Journal	Annals of Clinical and Translational Neurology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1002/acn3.51700
State	Published - Jan 2023
Externally published	Yes

Access to Document

10.1002/acn3.51700

Cite this

@article{7e5bb76b15854834a7571b5756d25c3a,

title = "Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume",

abstract = "Brain atrophy in multiple sclerosis (MS), as measured by percentage brain volume change (PBVC) from brain magnetic resonance imaging (MRI), has been established as an outcome parameter in clinical trials. It is unknown to what extent volume changes within different brain tissue compartments contribute to PBVC. We analyzed pairs of MRI scans (at least 6 months apart) in 600 patients with relapsing–remitting MS. Multiple regression revealed that PBVC mainly reflects volume loss of white and cortical gray matter, while deep gray matter and white matter lesions were less represented. Our findings aid the interpretation of PBVC changes in MS.",

author = "Markus Lauerer and Matthias Bussas and Viola Pongratz and Achim Berthele and Kirschke, {Jan S.} and Benedikt Wiestler and Claus Zimmer and Bernhard Hemmer and Mark M{\"u}hlau",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.",

year = "2023",

month = jan,

doi = "10.1002/acn3.51700",

language = "English",

volume = "10",

pages = "130--135",

journal = "Annals of Clinical and Translational Neurology",

issn = "2328-9503",

publisher = "John Wiley & Sons Inc.",

number = "1",

}

TY - JOUR

T1 - Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

AU - Lauerer, Markus

AU - Bussas, Matthias

AU - Pongratz, Viola

AU - Berthele, Achim

AU - Kirschke, Jan S.

AU - Wiestler, Benedikt

AU - Zimmer, Claus

AU - Hemmer, Bernhard

AU - Mühlau, Mark

PY - 2023/1

Y1 - 2023/1

N2 - Brain atrophy in multiple sclerosis (MS), as measured by percentage brain volume change (PBVC) from brain magnetic resonance imaging (MRI), has been established as an outcome parameter in clinical trials. It is unknown to what extent volume changes within different brain tissue compartments contribute to PBVC. We analyzed pairs of MRI scans (at least 6 months apart) in 600 patients with relapsing–remitting MS. Multiple regression revealed that PBVC mainly reflects volume loss of white and cortical gray matter, while deep gray matter and white matter lesions were less represented. Our findings aid the interpretation of PBVC changes in MS.

AB - Brain atrophy in multiple sclerosis (MS), as measured by percentage brain volume change (PBVC) from brain magnetic resonance imaging (MRI), has been established as an outcome parameter in clinical trials. It is unknown to what extent volume changes within different brain tissue compartments contribute to PBVC. We analyzed pairs of MRI scans (at least 6 months apart) in 600 patients with relapsing–remitting MS. Multiple regression revealed that PBVC mainly reflects volume loss of white and cortical gray matter, while deep gray matter and white matter lesions were less represented. Our findings aid the interpretation of PBVC changes in MS.

UR - http://www.scopus.com/inward/record.url?scp=85142726789&partnerID=8YFLogxK

U2 - 10.1002/acn3.51700

DO - 10.1002/acn3.51700

M3 - Article

C2 - 36427289

AN - SCOPUS:85142726789

SN - 2328-9503

VL - 10

SP - 130

EP - 135

JO - Annals of Clinical and Translational Neurology

JF - Annals of Clinical and Translational Neurology

IS - 1

ER -

Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

Abstract

Access to Document

Other files and links

Fingerprint

Cite this