Peptide vaccines get an OS update

Martin Zacharias, Sebastian Springer

Research output: Contribution to journalComment/debate


Peptide vaccines use antigenic peptide fragments to induce an immune response but are problematic because of the short half-life of peptides. A study now reports thioamide substitution in the peptide backbone as a strategy to enhance resistance to proteolysis and promote binding to the MHC I complex for T cell activation.

Original languageEnglish
Pages (from-to)549-550
Number of pages2
JournalNature Chemical Biology
Issue number5
StatePublished - May 2024
Externally publishedYes


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