Penetration of ciprofloxacin into the human pancreas

R. Isenmann, K. Fleischer, P. Schlegel, H. Frieß, M. W. Büchler

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The aim of this study was to determine the concentrations of ciprofloxacin in human pancreatic tissue and juice. Concentrations were measured by high-pressure liquid chromatography (HPLC). Two hundred mg of ciprofloxacin were administered as a short i. v. infusion (30 min). The median ciprofloxacin concentrations 140 min (median) after the start of infusion in pancreatic tissue as well as in pancreatic juice were 0.9 mg/kg (mg/l). The penetration ratio was 1.0 for pancreatic tissue and 0.83 for pancreatic juice. With regard to the minimal inhibitory concentrations (MIC) for the respective bacteria, ciprofloxacin seems to be an appropriate drug for the treatment of septic complications in necrotizing pancreatitis. Future clinical trials are necessary to prove this assumption.

Original languageEnglish
Pages (from-to)343-346
Number of pages4
JournalInfection
Volume22
Issue number5
DOIs
StatePublished - Sep 1994
Externally publishedYes

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