Pd-Catalyzed Cyanation of (Hetero)Aryl Halides by Using Biphosphine Ligands

Shaoke Zhang, Helfried Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Tetraadamantylbiphosphine (TABP; L1), which showed superior activity in the palladium-catalyzed cyanation of 4-chloroanisole compared to standard phosphines, was synthesized as a new ligand. The generality of the new catalytic system was shown by the cyanation reaction of approximately 30 (hetero)aryl halides including hindered, electron-rich, and electron-poor aryl chlorides. These reactions constitute the first examples of using biphosphine ligands in Pd-catalyzed coupling reactions.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalChemistry - A European Journal
Issue number1
StatePublished - 2 Jan 2018
Externally publishedYes


  • aryl halides
  • biphosphines
  • cyanation
  • palladium
  • synthetic methods


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