Pd-Catalyzed Carbonylation of Vinyl Triflates to Afford α,β-Unsaturated Aldehydes, Esters, and Amides under Mild Conditions

Shaoke Zhang, Helfried Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

An efficient and general protocol for the synthesis of α,β-unsaturated aldehydes, esters, and amides via carbonylation of vinyl triflates including derivatives of camphor, ketoisophorone, verbenone, and pulegone was developed. Crucial for these transformations is the use of a specific palladium catalyst containing a pyridyl-substituted dtbpx-type ligand. This procedure also allows for an easy access of dicarbonylated products from the corresponding ketones.

Original languageEnglish
Pages (from-to)3528-3532
Number of pages5
JournalOrganic Letters
Volume21
Issue number10
DOIs
StatePublished - 17 May 2019
Externally publishedYes

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