Patientenabgeleitete Tumororganoide – ein Therapiemodell für die Präzisionsonkologie

Linus R. Schömig; Michael Quante

doi:10.1007/s00761-022-01268-8

Patientenabgeleitete Tumororganoide – ein Therapiemodell für die Präzisionsonkologie

Translated title of the contribution: Patient-derived tumor organoids—a therapeutic model in precision oncology

Linus R. Schömig
, Michael Quante

University of Freiburg

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Organoids are three-dimensional, multicellular and stem-cell-derived in vitro tissue cultures with self-organizing and self-renewing capabilities. In the field of personalized treatment approaches, organoids can serve as a suitable treatment model for molecular and functional analyses, due to their high similarities to the primary tissue that they were derived from. Especially in the field of precision oncology, where a high demand for patient-specific therapy models remains, organoids can serve as an alternative to conventional two-dimensional tissue culture and patient-derived xenografts.

Translated title of the contribution	Patient-derived tumor organoids—a therapeutic model in precision oncology
Original language	German
Pages (from-to)	74-84
Number of pages	11
Journal	Onkologie
Volume	29
Issue number	1
DOIs	https://doi.org/10.1007/s00761-022-01268-8
State	Published - Jan 2023
Externally published	Yes

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title = "Patientenabgeleitete Tumororganoide – ein Therapiemodell f{\"u}r die Pr{\"a}zisionsonkologie",

abstract = "Organoids are three-dimensional, multicellular and stem-cell-derived in vitro tissue cultures with self-organizing and self-renewing capabilities. In the field of personalized treatment approaches, organoids can serve as a suitable treatment model for molecular and functional analyses, due to their high similarities to the primary tissue that they were derived from. Especially in the field of precision oncology, where a high demand for patient-specific therapy models remains, organoids can serve as an alternative to conventional two-dimensional tissue culture and patient-derived xenografts.",

keywords = "Functional analysis, Molecular tumor boards, Treatment model/oncology, Two-dimensional cell cultures, Xenografts, patient-derived",

author = "Sch{\"o}mig, \{Linus R.\} and Michael Quante",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.",

year = "2023",

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AU - Quante, Michael

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KW - Functional analysis

KW - Molecular tumor boards

KW - Treatment model/oncology

KW - Two-dimensional cell cultures

KW - Xenografts, patient-derived

UR - https://www.scopus.com/pages/publications/85150681724

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ER -

Patientenabgeleitete Tumororganoide – ein Therapiemodell für die Präzisionsonkologie

Abstract

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