TY - JOUR
T1 - Patientenabgeleitete Tumororganoide – ein Therapiemodell für die Präzisionsonkologie
AU - Schömig, Linus R.
AU - Quante, Michael
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.
PY - 2023/1
Y1 - 2023/1
N2 - Organoids are three-dimensional, multicellular and stem-cell-derived in vitro tissue cultures with self-organizing and self-renewing capabilities. In the field of personalized treatment approaches, organoids can serve as a suitable treatment model for molecular and functional analyses, due to their high similarities to the primary tissue that they were derived from. Especially in the field of precision oncology, where a high demand for patient-specific therapy models remains, organoids can serve as an alternative to conventional two-dimensional tissue culture and patient-derived xenografts.
AB - Organoids are three-dimensional, multicellular and stem-cell-derived in vitro tissue cultures with self-organizing and self-renewing capabilities. In the field of personalized treatment approaches, organoids can serve as a suitable treatment model for molecular and functional analyses, due to their high similarities to the primary tissue that they were derived from. Especially in the field of precision oncology, where a high demand for patient-specific therapy models remains, organoids can serve as an alternative to conventional two-dimensional tissue culture and patient-derived xenografts.
KW - Functional analysis
KW - Molecular tumor boards
KW - Treatment model/oncology
KW - Two-dimensional cell cultures
KW - Xenografts, patient-derived
UR - http://www.scopus.com/inward/record.url?scp=85150681724&partnerID=8YFLogxK
U2 - 10.1007/s00761-022-01268-8
DO - 10.1007/s00761-022-01268-8
M3 - Artikel
AN - SCOPUS:85150681724
SN - 2731-7226
VL - 29
SP - 74
EP - 84
JO - Onkologie
JF - Onkologie
IS - 1
ER -