Pathways and patterns of cell loss in verified Alzheimer's disease: A factor and cluster analysis of clinico-pathological subgroups

H. Forstl, R. Levy, A. Burns, P. Luthert, N. Cairns

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Thirty-seven patients with neuropathologically verified Alzheimer's disease (AD) have been studied prospectively. A principal components analysis of neuron numbers in cortical and subcortical areas revealed two variables: Variable I with high loadings for the hippocampo-parahippocampo-parietal neuron counts and Variable II with high loadings for coeruleo-frontal cell numbers. Both may reflect functional neuroanatomical connections which may act as pathways of neurodegeneration in AD. A cluster analysis based on these neuron numbers yielded three groups of patients: Cluster A with low hippocampo-parahippocampo-parietal cell counts, Cluster B with well-preserved neuron numbers, and Cluster C with low coeruleo-frontal neuron numbers. Differences in clinical features between these patient groups indicated the potential clinical relevance of these clusters.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalBehavioural Neurology
Volume7
Issue number3-4
StatePublished - 1994
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Neurodegeneration
  • Neuropathology
  • Sub-groups

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