TY - JOUR
T1 - Pathology of MEN-1
T2 - Morphology, clinicopathologic correlations and tumour development
AU - Komminoth, P.
AU - Heitz, P. U.
AU - Klöppel, G.
PY - 1998
Y1 - 1998
N2 - Multiple endocrine neoplasia type 1 (MEN-1) is an inherited syndrome which is characterized by the occurrence of neoplastic lesions in the parathyroids, the pancreas, duodenum, anterior pituitary and, less commonly, also in the stomach, thymus and lung. Its genetic defect has recently been identified and appears to involve a new type of tumour suppressor gene called mu on chromosome 11q13. In this overview, we will summarize the morphological features of the MEN-1 phenotype, discuss its clinicopathologic profile and prognosis and outline the recent findings on the molecular pathology of this syndrome.
AB - Multiple endocrine neoplasia type 1 (MEN-1) is an inherited syndrome which is characterized by the occurrence of neoplastic lesions in the parathyroids, the pancreas, duodenum, anterior pituitary and, less commonly, also in the stomach, thymus and lung. Its genetic defect has recently been identified and appears to involve a new type of tumour suppressor gene called mu on chromosome 11q13. In this overview, we will summarize the morphological features of the MEN-1 phenotype, discuss its clinicopathologic profile and prognosis and outline the recent findings on the molecular pathology of this syndrome.
KW - Clinicopathologic characteristics
KW - MEN-1 syndrome
KW - Molecular pathology
KW - Morphologic features
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=0031809241&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2796.1998.00274.x
DO - 10.1046/j.1365-2796.1998.00274.x
M3 - Article
C2 - 9681843
AN - SCOPUS:0031809241
SN - 0954-6820
VL - 243
SP - 455
EP - 464
JO - Journal of Internal Medicine
JF - Journal of Internal Medicine
IS - 6
ER -