Pathogenese der chronischen pankreatitis

Translated title of the contribution: Pathogenesis of chronic pancreatitis

Research output: Contribution to journalArticlepeer-review

Abstract

Long-term alcoholism and gene mutations are the most important risk factors for developing chronic pancreatitis. Genetic studies in the last two decades have revolutionized the understanding of the mechanisms mediating pancreatic damage. For a long time hereditary pancreatitis was thought to be a rare disease. The identification of mutations in digestive enzymes and their inhibitors in patients with idiopathic chronic pancreatitis showed that inherited cases of the disease are much commoner than initially believed. These findings question the differentiation between hereditary and idiopathic pancreatitis. The association between SPINK1 and CTRC mutations with tropical and alcoholic pancreatitis further blurs the border between the single subtypes. Most probably, future research will reveal a complex interaction between environmental and various genetic factors.

Translated title of the contributionPathogenesis of chronic pancreatitis
Original languageGerman
Pages (from-to)6-13
Number of pages8
JournalGastroenterologe
Volume9
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

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