Patch-clamping in slices of mammalian CNS

Arthur Konnerth

doi:10.1016/0166-2236(90)90137-Y

Patch-clamping in slices of mammalian CNS

Arthur Konnerth

Max Planck Institute for Biophysical Chemistry

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A new method has been developed that permits high-resolution patch-clamp recordings in neurones from slice preparations of virtually every region of the brain or spinal cord. Since in these preparations most of the synaptic contacts are intact, the method is particularly interesting for the investigation of the molecular mechanisms of synaptic transmission at identified central neurones.

Original language	English
Pages (from-to)	321-323
Number of pages	3
Journal	Trends in Neurosciences
Volume	13
Issue number	8
DOIs	https://doi.org/10.1016/0166-2236(90)90137-Y
State	Published - Aug 1990
Externally published	Yes

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10.1016/0166-2236(90)90137-Y

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title = "Patch-clamping in slices of mammalian CNS",

abstract = "A new method has been developed that permits high-resolution patch-clamp recordings in neurones from slice preparations of virtually every region of the brain or spinal cord. Since in these preparations most of the synaptic contacts are intact, the method is particularly interesting for the investigation of the molecular mechanisms of synaptic transmission at identified central neurones.",

author = "Arthur Konnerth",

note = "Funding Information: I am grateful to Drs 5. DeRiemer, B. Keller and Y. Yaarif or critically reading the manuscript. Work in the author's laboratory was supported by grants from the Deutsche Forschungsgemein schaf t (SFB2 36) and the Bundesministerium for Forschung und Technologie.",

year = "1990",

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N1 - Funding Information: I am grateful to Drs 5. DeRiemer, B. Keller and Y. Yaarif or critically reading the manuscript. Work in the author's laboratory was supported by grants from the Deutsche Forschungsgemein schaf t (SFB2 36) and the Bundesministerium for Forschung und Technologie.

PY - 1990/8

Y1 - 1990/8

N2 - A new method has been developed that permits high-resolution patch-clamp recordings in neurones from slice preparations of virtually every region of the brain or spinal cord. Since in these preparations most of the synaptic contacts are intact, the method is particularly interesting for the investigation of the molecular mechanisms of synaptic transmission at identified central neurones.

AB - A new method has been developed that permits high-resolution patch-clamp recordings in neurones from slice preparations of virtually every region of the brain or spinal cord. Since in these preparations most of the synaptic contacts are intact, the method is particularly interesting for the investigation of the molecular mechanisms of synaptic transmission at identified central neurones.

UR - https://www.scopus.com/pages/publications/0025358027

U2 - 10.1016/0166-2236(90)90137-Y

DO - 10.1016/0166-2236(90)90137-Y

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AN - SCOPUS:0025358027

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VL - 13

SP - 321

EP - 323

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 8

ER -

Patch-clamping in slices of mammalian CNS

Abstract

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