TY - GEN
T1 - PASTA
T2 - 27th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2024
AU - Li, Yitong
AU - Yakushev, Igor
AU - Hedderich, Dennis M.
AU - Wachinger, Christian
N1 - Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.
PY - 2024
Y1 - 2024
N2 - Positron emission tomography (PET) is a well-established functional imaging technique for diagnosing brain disorders. However, PET’s high costs and radiation exposure limit its widespread use. In contrast, magnetic resonance imaging (MRI) does not have these limitations. Although it also captures neurodegenerative changes, MRI is a less sensitive diagnostic tool than PET. To close this gap, we aim to generate synthetic PET from MRI. Herewith, we introduce PASTA, a novel pathology-aware image translation framework based on conditional diffusion models. Compared to the state-of-the-art methods, PASTA excels in preserving both structural and pathological details in the target modality, which is achieved through its highly interactive dual-arm architecture and multi-modal condition integration. A cycle exchange consistency and volumetric generation strategy elevate PASTA’s capability to produce high-quality 3D PET scans. Our qualitative and quantitative results confirm that the synthesized PET scans from PASTA not only reach the best quantitative scores but also preserve the pathology correctly. For Alzheimer’s classification, the performance of synthesized scans improves over MRI by 4%, almost reaching the performance of actual PET. Code is available at https://github.com/ai-med/PASTA.
AB - Positron emission tomography (PET) is a well-established functional imaging technique for diagnosing brain disorders. However, PET’s high costs and radiation exposure limit its widespread use. In contrast, magnetic resonance imaging (MRI) does not have these limitations. Although it also captures neurodegenerative changes, MRI is a less sensitive diagnostic tool than PET. To close this gap, we aim to generate synthetic PET from MRI. Herewith, we introduce PASTA, a novel pathology-aware image translation framework based on conditional diffusion models. Compared to the state-of-the-art methods, PASTA excels in preserving both structural and pathological details in the target modality, which is achieved through its highly interactive dual-arm architecture and multi-modal condition integration. A cycle exchange consistency and volumetric generation strategy elevate PASTA’s capability to produce high-quality 3D PET scans. Our qualitative and quantitative results confirm that the synthesized PET scans from PASTA not only reach the best quantitative scores but also preserve the pathology correctly. For Alzheimer’s classification, the performance of synthesized scans improves over MRI by 4%, almost reaching the performance of actual PET. Code is available at https://github.com/ai-med/PASTA.
UR - https://www.scopus.com/pages/publications/85212527782
U2 - 10.1007/978-3-031-72104-5_51
DO - 10.1007/978-3-031-72104-5_51
M3 - Conference contribution
AN - SCOPUS:85212527782
SN - 9783031721038
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 529
EP - 540
BT - Medical Image Computing and Computer Assisted Intervention – MICCAI 2024 - 27th International Conference, Proceedings
A2 - Linguraru, Marius George
A2 - Dou, Qi
A2 - Feragen, Aasa
A2 - Giannarou, Stamatia
A2 - Glocker, Ben
A2 - Lekadir, Karim
A2 - Schnabel, Julia A.
PB - Springer Science and Business Media Deutschland GmbH
Y2 - 6 October 2024 through 10 October 2024
ER -