Abstract
Human parvovirus B19 infection in pregnancy causes hydrops fetalis with resulting fetal loss. Preliminary results of a German multicenter study indicate that B19 infection may cause spontaneous abortions accounting for approximately 2% of all abortions after the 14th week of gestation. Routine virological investigations revealed acute B19 infection in 120 pregnant women, 94 (78.3%) of whom delivered healthy babies and 26 (21.7%) aborted spontaneously. Fetal tissues were examined in 19 (73.1%) of 26 abortions. Of these 19 abortions, B19-DNA was detected in 14 (73.7%) fetuses. In total, of 120 pregnant women with acute B19 infection, B19 related abortion occurred in 14 (11.7%) of women. Fetal B19 infection was detected by standard histological staining methods and in situ hybridization using a Digoxigenin-labelled B19-DNA probe.
| Original language | English |
|---|---|
| Pages (from-to) | 219-223 |
| Number of pages | 5 |
| Journal | International Journal of Experimental and Clinical Chemotherapy |
| Volume | 3 |
| Issue number | 4 |
| State | Published - 1990 |
| Externally published | Yes |
