Parallel reactor systems for bioprocess development

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

68 Scopus citations


Controlled parallel bioreactor systems allow fed-batch operation at early stages of process development. The characteristics of shaken bioreactors operated in parallel (shake flask, microtiter plate), sparged bioreactors (small-scale bubble column) and stirred bioreactors (stirred-tank, stirred column) are briefly summarized. Parallel fed-batch operation is achieved with an intermittent feeding and pH-control system for up to 16 bioreactors operated in parallel on a scale of 100 ml. Examples of the scale-up and scale-down of pH-controlled microbial fed-batch processes demonstrate that controlled parallel reactor systems can result in more effective bioprocess development. Future developments are also outlined, including units of 48 parallel stirred-tank reactors with individual pH- and pO2-controls and automation as well as liquid handling system, operated on a scale of ml.

Original languageEnglish
Title of host publicationTechnology Transfer in Biotechnology
Subtitle of host publicationFrom lab to Industry to Production
Number of pages19
StatePublished - 28 Jan 2005

Publication series

NameAdvances in Biochemical Engineering/Biotechnology
ISSN (Print)0724-6145


  • Bioprocess development
  • Intermittent feeding
  • Parallel bioreactors
  • Parallel control
  • Scale-up/scale-down


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