Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection

Eugene Kroon; Suthat Chottanapund; Supranee Buranapraditkun; Carlo Sacdalan; Donn J. Colby; Nitiya Chomchey; Peeriya Prueksakaew; Suteeraporn Pinyakorn; Rapee Trichavaroj; Sandhya Vasan; Sopark Manasnayakorn; Cavan Reilly; Erika Helgeson; Jodi Anderson; Caitlin David; Jacob Zulk; Mark De Souza; Sodsai Tovanabutra; Alexandra Schuetz; Merlin L. Robb; Daniel C. Douek; Nittaya Phanuphak; Ashley Haase; Jintanat Ananworanich; Timothy W. Schacker

doi:10.1093/infdis/jiac089

Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection

Eugene Kroon, Suthat Chottanapund, Supranee Buranapraditkun, Carlo Sacdalan, Donn J. Colby, Nitiya Chomchey, Peeriya Prueksakaew, Suteeraporn Pinyakorn, Rapee Trichavaroj, Sandhya Vasan, Sopark Manasnayakorn, Cavan Reilly, Erika Helgeson, Jodi Anderson, Caitlin David, Jacob Zulk, Mark De Souza, Sodsai Tovanabutra, Alexandra Schuetz, Merlin L. RobbDaniel C. Douek, Nittaya Phanuphak, Ashley Haase, Jintanat Ananworanich, Timothy W. Schacker

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. To better understand why the reduced reservoir size did not increase the time to rebound we measured the frequency and location of HIV RNA+ cells in lymph nodes from participants in the RV254 acute infection cohort. HIV RNA+ cells were detected more frequently and in greater numbers when ART was initiated in Fiebig 1 compared to later Fiebig stages and were localized to the T-cell zone compared to the B-cell follicle with treatment in later Fiebig stages. Variability of virus production in people treated during acute infection suggests that the balance between virus-producing cells and the immune response to clear infected cells rapidly evolves during the earliest stages of infection. Clinical Trials Registration: NCT02919306.

Original language	English
Pages (from-to)	2167-2175
Number of pages	9
Journal	Journal of Infectious Diseases
Volume	225
Issue number	12
DOIs	https://doi.org/10.1093/infdis/jiac089
State	Published - 15 Jun 2022
Externally published	Yes

Keywords

HIV reservoir
acute HIV infection
antiretroviral therapy
in situ hybridization
lymphoid tissues

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiac089

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Kroon, E., Chottanapund, S., Buranapraditkun, S., Sacdalan, C., Colby, D. J., Chomchey, N., Prueksakaew, P., Pinyakorn, S., Trichavaroj, R., Vasan, S., Manasnayakorn, S., Reilly, C., Helgeson, E., Anderson, J., David, C., Zulk, J., De Souza, M., Tovanabutra, S., Schuetz, A., ... Schacker, T. W. (2022). Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection. Journal of Infectious Diseases, 225(12), 2167-2175. https://doi.org/10.1093/infdis/jiac089

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title = "Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection",

abstract = "Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. To better understand why the reduced reservoir size did not increase the time to rebound we measured the frequency and location of HIV RNA+ cells in lymph nodes from participants in the RV254 acute infection cohort. HIV RNA+ cells were detected more frequently and in greater numbers when ART was initiated in Fiebig 1 compared to later Fiebig stages and were localized to the T-cell zone compared to the B-cell follicle with treatment in later Fiebig stages. Variability of virus production in people treated during acute infection suggests that the balance between virus-producing cells and the immune response to clear infected cells rapidly evolves during the earliest stages of infection. Clinical Trials Registration: NCT02919306.",

keywords = "HIV reservoir, acute HIV infection, antiretroviral therapy, in situ hybridization, lymphoid tissues",

author = "Eugene Kroon and Suthat Chottanapund and Supranee Buranapraditkun and Carlo Sacdalan and Colby, {Donn J.} and Nitiya Chomchey and Peeriya Prueksakaew and Suteeraporn Pinyakorn and Rapee Trichavaroj and Sandhya Vasan and Sopark Manasnayakorn and Cavan Reilly and Erika Helgeson and Jodi Anderson and Caitlin David and Jacob Zulk and {De Souza}, Mark and Sodsai Tovanabutra and Alexandra Schuetz and Robb, {Merlin L.} and Douek, {Daniel C.} and Nittaya Phanuphak and Ashley Haase and Jintanat Ananworanich and Schacker, {Timothy W.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America.",

year = "2022",

month = jun,

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doi = "10.1093/infdis/jiac089",

language = "English",

volume = "225",

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Kroon, E, Chottanapund, S, Buranapraditkun, S, Sacdalan, C, Colby, DJ, Chomchey, N, Prueksakaew, P, Pinyakorn, S, Trichavaroj, R, Vasan, S, Manasnayakorn, S, Reilly, C, Helgeson, E, Anderson, J, David, C, Zulk, J, De Souza, M, Tovanabutra, S, Schuetz, A, Robb, ML, Douek, DC, Phanuphak, N, Haase, A, Ananworanich, J & Schacker, TW 2022, 'Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection', Journal of Infectious Diseases, vol. 225, no. 12, pp. 2167-2175. https://doi.org/10.1093/infdis/jiac089

TY - JOUR

T1 - Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection

AU - Kroon, Eugene

AU - Chottanapund, Suthat

AU - Buranapraditkun, Supranee

AU - Sacdalan, Carlo

AU - Colby, Donn J.

AU - Chomchey, Nitiya

AU - Prueksakaew, Peeriya

AU - Pinyakorn, Suteeraporn

AU - Trichavaroj, Rapee

AU - Vasan, Sandhya

AU - Manasnayakorn, Sopark

AU - Reilly, Cavan

AU - Helgeson, Erika

AU - Anderson, Jodi

AU - David, Caitlin

AU - Zulk, Jacob

AU - De Souza, Mark

AU - Tovanabutra, Sodsai

AU - Schuetz, Alexandra

AU - Robb, Merlin L.

AU - Douek, Daniel C.

AU - Phanuphak, Nittaya

AU - Haase, Ashley

AU - Ananworanich, Jintanat

AU - Schacker, Timothy W.

PY - 2022/6/15

Y1 - 2022/6/15

N2 - Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. To better understand why the reduced reservoir size did not increase the time to rebound we measured the frequency and location of HIV RNA+ cells in lymph nodes from participants in the RV254 acute infection cohort. HIV RNA+ cells were detected more frequently and in greater numbers when ART was initiated in Fiebig 1 compared to later Fiebig stages and were localized to the T-cell zone compared to the B-cell follicle with treatment in later Fiebig stages. Variability of virus production in people treated during acute infection suggests that the balance between virus-producing cells and the immune response to clear infected cells rapidly evolves during the earliest stages of infection. Clinical Trials Registration: NCT02919306.

AB - Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. To better understand why the reduced reservoir size did not increase the time to rebound we measured the frequency and location of HIV RNA+ cells in lymph nodes from participants in the RV254 acute infection cohort. HIV RNA+ cells were detected more frequently and in greater numbers when ART was initiated in Fiebig 1 compared to later Fiebig stages and were localized to the T-cell zone compared to the B-cell follicle with treatment in later Fiebig stages. Variability of virus production in people treated during acute infection suggests that the balance between virus-producing cells and the immune response to clear infected cells rapidly evolves during the earliest stages of infection. Clinical Trials Registration: NCT02919306.

KW - HIV reservoir

KW - acute HIV infection

KW - antiretroviral therapy

KW - in situ hybridization

KW - lymphoid tissues

UR - http://www.scopus.com/inward/record.url?scp=85132452194&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiac089

DO - 10.1093/infdis/jiac089

M3 - Article

C2 - 35275599

AN - SCOPUS:85132452194

SN - 0022-1899

VL - 225

SP - 2167

EP - 2175

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 12

ER -

Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection

Abstract

Keywords

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