TY - JOUR
T1 - Paper-based electrochemical device for early detection of integrin αvβ6 expressing tumors
AU - Cinti, Stefano
AU - Tomassi, Stefano
AU - Ciardiello, Chiara
AU - Migliorino, Rossella
AU - Pirozzi, Marinella
AU - Leone, Alessandra
AU - Di Gennaro, Elena
AU - Campani, Virginia
AU - De Rosa, Giuseppe
AU - D’Amore, Vincenzo Maria
AU - Di Maro, Salvatore
AU - Donati, Greta
AU - Singh, Sima
AU - Raucci, Ada
AU - Di Leva, Francesco Saverio
AU - Kessler, Horst
AU - Budillon, Alfredo
AU - Marinelli, Luciana
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Despite progress in the prevention and diagnosis of cancer, current technologies for tumor detection present several limitations including invasiveness, toxicity, inaccuracy, lengthy testing duration and high cost. Therefore, innovative diagnostic techniques that integrate knowledge from biology, oncology, medicinal and analytical chemistry are now quickly emerging in the attempt to address these issues. Following this approach, here we developed a paper-based electrochemical device for detecting cancer-derived Small Extracellular Vesicles (S-EVs) in fluids. S-EVs were obtained from cancer cell lines known to express, at a different level, the αvβ6 integrin receptor, a well-established hallmark of numerous epithelial cancer types. The resulting biosensor turned out to recognize αvβ6-containing S-EVs down to a limit of 0.7*103 S-EVs/mL with a linear range up to 105 S-EVs /mL, and a relative standard deviation of 11%, thus it may represent a novel opportunity for αvβ6 expressing cancers detection.
AB - Despite progress in the prevention and diagnosis of cancer, current technologies for tumor detection present several limitations including invasiveness, toxicity, inaccuracy, lengthy testing duration and high cost. Therefore, innovative diagnostic techniques that integrate knowledge from biology, oncology, medicinal and analytical chemistry are now quickly emerging in the attempt to address these issues. Following this approach, here we developed a paper-based electrochemical device for detecting cancer-derived Small Extracellular Vesicles (S-EVs) in fluids. S-EVs were obtained from cancer cell lines known to express, at a different level, the αvβ6 integrin receptor, a well-established hallmark of numerous epithelial cancer types. The resulting biosensor turned out to recognize αvβ6-containing S-EVs down to a limit of 0.7*103 S-EVs/mL with a linear range up to 105 S-EVs /mL, and a relative standard deviation of 11%, thus it may represent a novel opportunity for αvβ6 expressing cancers detection.
UR - http://www.scopus.com/inward/record.url?scp=85188293180&partnerID=8YFLogxK
U2 - 10.1038/s42004-024-01144-z
DO - 10.1038/s42004-024-01144-z
M3 - Article
AN - SCOPUS:85188293180
SN - 2399-3669
VL - 7
JO - Communications Chemistry
JF - Communications Chemistry
IS - 1
M1 - 60
ER -
