Pancreatic enzyme replacement therapy in patients with exocrine pancreatic insufficiency due to chronic pancreatitis: A 1-year disease management study on symptom control and quality of life

Jan G. D'Haese, Güralp O. Ceyhan, Ihsan Ekin Demir, Peter Layer, Waldemar Uhl, Matthias Löhr, Reinhard Rychlik, Konstantinos Pirilis, York Zöllner, Birgit Gradl, Douglas Foerster, Julia Möbius, Friederike Henniges, Helmut Friess

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Objective: Exocrine pancreatic insufficiency (EPI) is frequent in patients with chronic pancreatitis (CP). This 1-year, prospective, multicenter, observational, disease management study aimed to assess symptom improvement and quality of life in patients with CP with EPI who were receiving pancreatic enzyme replacement. Methods: Patients with CP and chronic EPI were either assigned to cohort 1 that consisted of patients already taking pancreatin (Kreon; Abbott Arzneimittel GmbH, Hannover, Germany) or cohort 2 that consisted of patients with newly diagnosed EPI without prior pancreatic enzyme treatment. Symptoms were documented, and quality of life was assessed using the gastrointestinal quality of life index (GIQLI) at baseline, 6 months, and 1 year. Results: A total of 294 patients were evaluated (cohort 1, n = 206; cohort 2, n = 88). The proportion of patients experiencing gastrointestinal symptoms and recurrent pain after 1 year was significantly reduced in both cohorts (P < 0.001). The alleviation of symptoms was reflected in GIQLI score improvements at 1 year in both cohorts (P < 0.001), independent of CP severity and etiology. Improvements in GIQLI score were more pronounced in cohort 2 (P < 0.001). Conclusions: Pancreatin demonstrated symptom relief and improvement in quality of life in patients with CP-related EPI in this disease management study.

Original languageEnglish
Pages (from-to)834-841
Number of pages8
JournalPancreas
Volume43
Issue number6
DOIs
StatePublished - Aug 2014
Externally publishedYes

Keywords

  • Kreon/Creon
  • disease management research
  • exocrine pancreatic insufficiency
  • gastrointestinal quality of life index
  • pancreatic enzyme replacement

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