Pancreatic endocrine carcinoma with ectopic PTH-production and paraneoplastic hypercalcaemia

Hartmut Arps; Manfred Dietel; Andreas Schulz; Hilde Janzarik; Günther Klöppel

doi:10.1007/BF00705303

Pancreatic endocrine carcinoma with ectopic PTH-production and paraneoplastic hypercalcaemia

Hartmut Arps, Manfred Dietel, Andreas Schulz, Hilde Janzarik, Günther Klöppel

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

In a case of pancreatic endocrine carcinoma hypercalcaemia without bone metastases and normal parathyroid glands prompted our suspicion that there was paraneoplastic production of an osteoclast activating substance by the tumour tissue. This view was further confirmed by bone histology. Immunohistology post mortem revealed the production of PTH in the primary tumour and a liver metastasis. The usefulness of immunohistology in detecting paraneoplastic secretion of hormonal substances is discussed.

Original language	English
Pages (from-to)	497-503
Number of pages	7
Journal	Virchows Archiv A Pathological Anatomy and Histopathology
Volume	408
Issue number	5
DOIs	https://doi.org/10.1007/BF00705303
State	Published - Sep 1986
Externally published	Yes

Keywords

Immunohistology
Pancreatic endocrine carcinoma
Paraneoplasia
Parathyroid hormone

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10.1007/BF00705303

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title = "Pancreatic endocrine carcinoma with ectopic PTH-production and paraneoplastic hypercalcaemia",

abstract = "In a case of pancreatic endocrine carcinoma hypercalcaemia without bone metastases and normal parathyroid glands prompted our suspicion that there was paraneoplastic production of an osteoclast activating substance by the tumour tissue. This view was further confirmed by bone histology. Immunohistology post mortem revealed the production of PTH in the primary tumour and a liver metastasis. The usefulness of immunohistology in detecting paraneoplastic secretion of hormonal substances is discussed.",

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author = "Hartmut Arps and Manfred Dietel and Andreas Schulz and Hilde Janzarik and G{\"u}nther Kl{\"o}ppel",

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AU - Arps, Hartmut

AU - Dietel, Manfred

AU - Schulz, Andreas

AU - Janzarik, Hilde

AU - Klöppel, Günther

PY - 1986/9

Y1 - 1986/9

N2 - In a case of pancreatic endocrine carcinoma hypercalcaemia without bone metastases and normal parathyroid glands prompted our suspicion that there was paraneoplastic production of an osteoclast activating substance by the tumour tissue. This view was further confirmed by bone histology. Immunohistology post mortem revealed the production of PTH in the primary tumour and a liver metastasis. The usefulness of immunohistology in detecting paraneoplastic secretion of hormonal substances is discussed.

AB - In a case of pancreatic endocrine carcinoma hypercalcaemia without bone metastases and normal parathyroid glands prompted our suspicion that there was paraneoplastic production of an osteoclast activating substance by the tumour tissue. This view was further confirmed by bone histology. Immunohistology post mortem revealed the production of PTH in the primary tumour and a liver metastasis. The usefulness of immunohistology in detecting paraneoplastic secretion of hormonal substances is discussed.

KW - Immunohistology

KW - Pancreatic endocrine carcinoma

KW - Paraneoplasia

KW - Parathyroid hormone

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IS - 5

ER -

Pancreatic endocrine carcinoma with ectopic PTH-production and paraneoplastic hypercalcaemia

Abstract

Keywords

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