Pancreatic acinar cell carcinoma with excessive alpha-fetoprotein expression

P. Kolb-Van Harten; U. Rosien; G. Klöppel; P. Layer

doi:10.1159/000107397

Pancreatic acinar cell carcinoma with excessive alpha-fetoprotein expression

P. Kolb-Van Harten
, U. Rosien
, G. Klöppel
, P. Layer

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We report a case of acinar cell carcinoma of the pancreas associated with excessively elevated levels of serum α-fetoprotein (>32,000 ng/ml). Abdominal computed tomography scan revealed a large pancreatic mass with infiltration of the splenic artery. Because of inoperability, palliative combination chemotherapy with gemcitabine and mitomycin C was administered. This regimen was associated with clinical improvement and dramatic decreases in both tumor size and serum α-fetoprotein. However, the patient died 7 months later from acute severe cardiac failure.

Original language	English
Pages (from-to)	370-372
Number of pages	3
Journal	Pancreatology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1159/000107397
State	Published - Sep 2007
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Gemcitabine
Mitomycin c
Palliative chemotherapy
Pancreas
Pancreatic acinar cell carcinoma
α-Fetoprotein

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10.1159/000107397

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title = "Pancreatic acinar cell carcinoma with excessive alpha-fetoprotein expression",

abstract = "We report a case of acinar cell carcinoma of the pancreas associated with excessively elevated levels of serum α-fetoprotein (>32,000 ng/ml). Abdominal computed tomography scan revealed a large pancreatic mass with infiltration of the splenic artery. Because of inoperability, palliative combination chemotherapy with gemcitabine and mitomycin C was administered. This regimen was associated with clinical improvement and dramatic decreases in both tumor size and serum α-fetoprotein. However, the patient died 7 months later from acute severe cardiac failure.",

keywords = "Gemcitabine, Mitomycin c, Palliative chemotherapy, Pancreas, Pancreatic acinar cell carcinoma, α-Fetoprotein",

author = "\{Kolb-Van Harten\}, P. and U. Rosien and G. Kl{\"o}ppel and P. Layer",

year = "2007",

month = sep,

doi = "10.1159/000107397",

language = "English",

volume = "7",

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journal = "Pancreatology",

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T1 - Pancreatic acinar cell carcinoma with excessive alpha-fetoprotein expression

AU - Kolb-Van Harten, P.

AU - Rosien, U.

AU - Klöppel, G.

AU - Layer, P.

PY - 2007/9

Y1 - 2007/9

N2 - We report a case of acinar cell carcinoma of the pancreas associated with excessively elevated levels of serum α-fetoprotein (>32,000 ng/ml). Abdominal computed tomography scan revealed a large pancreatic mass with infiltration of the splenic artery. Because of inoperability, palliative combination chemotherapy with gemcitabine and mitomycin C was administered. This regimen was associated with clinical improvement and dramatic decreases in both tumor size and serum α-fetoprotein. However, the patient died 7 months later from acute severe cardiac failure.

AB - We report a case of acinar cell carcinoma of the pancreas associated with excessively elevated levels of serum α-fetoprotein (>32,000 ng/ml). Abdominal computed tomography scan revealed a large pancreatic mass with infiltration of the splenic artery. Because of inoperability, palliative combination chemotherapy with gemcitabine and mitomycin C was administered. This regimen was associated with clinical improvement and dramatic decreases in both tumor size and serum α-fetoprotein. However, the patient died 7 months later from acute severe cardiac failure.

KW - Gemcitabine

KW - Mitomycin c

KW - Palliative chemotherapy

KW - Pancreas

KW - Pancreatic acinar cell carcinoma

KW - α-Fetoprotein

UR - https://www.scopus.com/pages/publications/34748881841

U2 - 10.1159/000107397

DO - 10.1159/000107397

M3 - Article

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AN - SCOPUS:34748881841

SN - 1424-3903

VL - 7

SP - 370

EP - 372

JO - Pancreatology

JF - Pancreatology

IS - 4

ER -

Pancreatic acinar cell carcinoma with excessive alpha-fetoprotein expression

Abstract

UN SDGs

Keywords

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