Palladium/di-1-adamantyl-n-butylphosphine-catalyzed reductive carbonylation of aryl and vinyl halides

Anne Brennführer, Helfried Neumann, Stefan Klaus, Thomas Riermeier, Juan Almena, Matthias Beller

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

A general and efficient palladium-catalyzed reductive carbonylation with low catalyst loadings (0.5 mol % Pd or below) has been developed. The formylation of aryl and heteroaryl bromides proceeds smoothly in the presence of palladium/di-1-adamantyl-n-butylphosphine at ambient pressure of synthesis gas to afford the corresponding aromatic aldehydes in good yields and excellent selectivity. In addition, vinyl halides react under similar conditions to form α,β-unsaturated aldehydes in good yield.

Original languageEnglish
Pages (from-to)6252-6258
Number of pages7
JournalTetrahedron
Volume63
Issue number27
DOIs
StatePublished - 2 Jul 2007
Externally publishedYes

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