Palladium-catalyzed synthesis of substituted hydantoins - A new carbonylation reaction for the synthesis of amino acid derivatives

Matthias Beller, Markus Eckert, Wahed A. Moradi, Helfried Neumann

Research output: Contribution to journalArticlepeer-review

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Abstract

One-step synthesis of substituted hydantoins can be achieved by the palladium-catalyzed 'ureidocarbonylation' of aldehydes with urea derivatives and carbon monoxide [Eq. (1)]. This surprisingly selective protocol converts substituted ureas into 1,5- and 1,3,5-substituted hydantoins in yields of up to 93 %.

Original languageEnglish
Pages (from-to)1454-1457
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume38
Issue number10
DOIs
StatePublished - 17 May 1999
Externally publishedYes

Keywords

  • Amino acids
  • Carbonylations
  • Hydantoins
  • Palladium
  • Ureidocarbonylations

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