Palladium-catalyzed synthesis of phthalazinones: Efficient carbonylative coupling of 2-bromobenzaldehydes and hydrazines

Xiao Feng Wu, Helfried Neumann, Stephan Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Phthalazinones made easy! A new, straightforward methodology for the carbonylative synthesis of phthalazinones has been established. Starting from readily available 2-bromobenzaldehydes or 2-bromoacetophenone and hydrazines, a variety of phthalazinones have been produced in good isolated yields (see scheme).

Original languageEnglish
Pages (from-to)8596-8599
Number of pages4
JournalChemistry - A European Journal
Volume18
Issue number28
DOIs
StatePublished - 9 Jul 2012
Externally publishedYes

Keywords

  • carbonylation
  • heterocycles
  • hydrazines
  • palladium
  • phthalazinones

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