Palladium-catalyzed synthesis of isoindoloquinazolinones via dicarbonylation of 1,2-dibromoarenes

Jianbin Chen, Helfried Neumann, Matthias Beller, Xiao Feng Wu

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

A convenient procedure for the carbonylative synthesis of isoindoloquinazolinones has been developed. Using 1,2-dibromobenzenes and 2-aminobenzyl amine as substrates and palladium as the catalyst, the desired products were isolated in moderate to good yields with the installation of two molecules of carbon monoxide. Notably, this is the first example of carbonylative synthesis of batracylin analogues. This journal is

Original languageEnglish
Pages (from-to)5835-5838
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number31
DOIs
StatePublished - 21 Aug 2014
Externally publishedYes

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