Palladium-catalyzed oxidative carbonylative coupling of arylboronic acids with terminal alkynes to alkynones

Kishore Natte, Jianbin Chen, Helfried Neumann, Matthias Beller, Xiao Feng Wu

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

We describe here an interesting palladium-catalyzed oxidative carbonylation of arylboronic acids with terminal alkynes. By the appropriate combination of a palladium salt, a ligand, and an oxidant, the desired alkynones were isolated in moderate to good yields. Notably, all the reactions were performed at room temperature, and moisture and air can be tolerated by this procedure. More importantly, this is the first example of oxidative carbonylative coupling of arylboronic acids with alkynes which filled the missing link in carbonylative coupling reactions.

Original languageEnglish
Pages (from-to)5590-5593
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number30
DOIs
StatePublished - 14 Aug 2014
Externally publishedYes

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