Palladium-Catalyzed Hydroamidocarbonylation of Olefins to Imides

Haoquan Li, Kaiwu Dong, Helfried Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Carbonylation reactions allow the efficient synthesis of all kinds of carbonyl-containing compounds. Here, we report a straightforward synthesis of various imides from olefins and CO for the first time. The established hydroamidocarbonylation reaction affords imides in good yields (up to 90%) and with good regioselectivity (up to 99:1) when applying different alkenes and amides. The synthetic potential of the method is highlighted by the synthesis of Aniracetam by intramolecular hydroamidocarbonylation.

Original languageEnglish
Pages (from-to)10239-10243
Number of pages5
JournalAngewandte Chemie International Edition in English
Issue number35
StatePublished - 1 Aug 2015
Externally publishedYes


  • alkenes
  • amides
  • carbonylation
  • homogeneous catalysis
  • imides


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