Abstract
The apparent and the real: What looks like a Friedel-Crafts alkylation reaction of electron-deficient pyrroles is actually a PdII-catalyzed, norbornene-mediated C-H activation reaction, in which the alkylation of the pyrrole core occurs by reductive elimination. As well as ethyl-1H-pyrrole-2- carboxylate (see scheme), several other 2,3-disubstituted pyrroles underwent the selective C5 alkylation in good yield.
Original language | English |
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Pages (from-to) | 6080-6083 |
Number of pages | 4 |
Journal | Angewandte Chemie International Edition in English |
Volume | 52 |
Issue number | 23 |
DOIs | |
State | Published - 3 Jun 2013 |
Keywords
- C-H activation
- alkylation
- heterocycles
- homogeneous catalysis
- palladium